钙拮抗剂与地西泮在减轻乙醇戒断震颤方面的比较。
A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors.
作者信息
Bone G H, Majchrowicz E, Martin P R, Linnoila M, Nutt D J
机构信息
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
出版信息
Psychopharmacology (Berl). 1989;99(3):386-8. doi: 10.1007/BF00445563.
PMID:2594904
Abstract
The calcium antagonists nimodipine and dantrolene were compared with diazepam in an animal model of tolerance and physical dependence upon ethanol. Nimodipine and dantrolene were both effective in suppressing withdrawal tremors but diazepam was clearly superior to both agents. These results suggest that the ethanol withdrawal syndrome is only partially mediated by increased calcium flux.
摘要
在乙醇耐受和身体依赖的动物模型中，将钙拮抗剂尼莫地平和丹曲林与地西泮进行了比较。尼莫地平和丹曲林在抑制戒断性震颤方面均有效，但地西泮明显优于这两种药物。这些结果表明，乙醇戒断综合征仅部分由钙通量增加介导。
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