Ghosh Sambuddha, Haldar Pampa, Ravindran Prashanth, Chatterjee Jyotirmoy, Paranjape Sandeep V, Bhaduri Gautam
Department of Ophthalmology, North Bengal Medical College, West Bengal, India.
Department of Ophthalmology, RG Kar Medical College, Kolkata, West Bengal, India.
Middle East Afr J Ophthalmol. 2015 Apr-Jun;22(2):186-91. doi: 10.4103/0974-9233.151869.
The aim of this study was to evaluate choroidal neovascular (CNV) lesions with fluorescein angiography (FA) and to identify quantitative parameters and correlate these parameters to treatment outcomes.
This institution based cross-sectional study evaluated 30 eyes with active sub-foveal predominantly classic CNV treated with bevacizumab. Pre- and post-injection segmented FA images were analyzed. Lesion area and CNV lesion were manually delineated. Outcome measure was the change 1-month after each injection in different intensity values (0-255 divided in eight regions A [lowest intensity] to H [highest intensity] on a linear scale) in lesion area, perimeter, greatest linear dimension (GLD), area, visual acuity (VA) and central macular thickness (CMT).
At month 3, statistically significant changes from baseline occurred in VA, CMT, lesion area, GLD and perimeter (P < 0.05 all comparisons). Change in CMT from baseline to 3 months postinjection was correlated with change in VA (P = 0.009, r = 0.469) and intensity regions B (P = 0.001, r = -0.565), D (P = 0.001, r = 0.560), E (P = 0.035, r = 0.386). At month 3, change in intensity values 0-63 (A + B) was negatively correlated with CMT (P = 0.001, r = -0.575) and lesion area (P = 0.019, r = -0.427); change in intensity values 64-223 (C-G) was positively correlated with CMT (P = 0.000, r = 0.636) and lesion area (P = 0.002, r = 0.551).
Decrease in area, GLD, perimeter and area with intensity ≥ 64 on segmented FA were associated with a favorable outcome of treatment. These parameters may be useful adjuncts to existing evaluation techniques during follow-up of CNV.
本研究旨在通过荧光素血管造影（FA）评估脉络膜新生血管（CNV）病变，确定定量参数，并将这些参数与治疗结果相关联。
本机构的横断面研究评估了30只接受贝伐单抗治疗的活动性黄斑中心凹下以典型CNV为主的眼睛。分析注射前和注射后的分段FA图像。手动勾勒病变区域和CNV病变。结果测量指标为每次注射后1个月时病变区域、周长、最大线性尺寸（GLD）、面积、视力（VA）和中心黄斑厚度（CMT）在不同强度值（0 - 255，在线性尺度上分为八个区域A[最低强度]至H[最高强度]）的变化。
在第3个月时，VA、CMT、病变区域、GLD和周长与基线相比发生了具有统计学意义的变化（所有比较P < 0.05）。注射后从基线到3个月时CMT的变化与VA的变化相关（P = 0.009，r = 0.469），与强度区域B（P = 0.001，r = -0.565）以及D（P = 0.001，r = 0.560）、E（P = 0.035，r = 0.386）相关。在第3个月时，强度值0 - 63（A + B）的变化与CMT（P = 0.001，r = -0.575）和病变区域（P = 0.019，r = -0.427）呈负相关；强度值64 - 223（C - G）的变化与CMT（P = 0.000，r = 0.636）和病变区域（P = 0.002，r = 0.551）呈正相关。
在分段FA上，面积、GLD、周长以及强度≥64时的面积减小与治疗的良好结果相关。这些参数在CNV随访期间可能是现有评估技术的有用辅助指标。
