年轻女性特发性视乳头周围视网膜下新生血管膜，玻璃体腔注射贝伐单抗治疗后孕期病变复发

Al-Gharbi Nasra, Al Abdulsalam Omar, Al Habash Ahmed

Division of Vitreoretinal, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

Depatment of Ophthalmology, King Abdulaziz Hospital, Al Ahsa, National Guard Health Affairs, Saudi Arabia.

Middle East Afr J Ophthalmol. 2015 Apr-Jun;22(2):245-8. doi: 10.4103/0974-9233.150639.

We report a 27-year-old woman who was diagnosed with idiopathic peripapillary subretinal neovascular membrane (PSRNVM) in her left eye with best-corrected visual acuity (BCVA) of 20/160. She had been treated by three monthly doses of intravitreal bevacizumab (1.25 mg/0.05 ml) at 4-week intervals, which showed a favorable response. The treatment led to regression of the choroidal neovascular membrane (CNVM) with complete resorption of subretinal fluid and improvement of BCVA to 20/25. Subsequently, recurrence of the CNVM was observed during pregnancy (28 months after treatment). To the best of our knowledge, this is the first report of recurrence of idiopathic PSRNVM during pregnancy.

我们报告了一名27岁女性，其左眼被诊断为特发性视乳头周围视网膜下新生血管膜（PSRNVM），最佳矫正视力（BCVA）为20/160。她接受了每月一次、共三次剂量的玻璃体内注射贝伐单抗（1.25毫克/0.05毫升）治疗，间隔4周，治疗效果良好。治疗导致脉络膜新生血管膜（CNVM）消退，视网膜下液完全吸收，BCVA提高到20/25。随后，在怀孕期（治疗后28个月）观察到CNVM复发。据我们所知，这是第一例关于特发性PSRNVM在孕期复发的报告。