Oh Seunghoon
Dept. of Physiology, College of Medicine, Dankook University, Cheonan 330-714, Korea.
Dev Reprod. 2014 Dec;18(4):187-95. doi: 10.12717/devrep.2014.18.4.187.
Polycyclic aromatic hydevrepocarbons (PAHs), which are ubiquitous in the air, are present as volatile and particulate pollutants that result from incomplete combustion. Most PAHs have toxic, mutagenic, and/or carcinogenic properties. Among PAHs, benzo[a]pyrene (B[a]P) and dimethylbenz[a]anthracene (DMBA) are suspected endocrine disruptors. The testis is an important target for PAHs, yet effects on steroidogenesis in Leydig cells are yet to be ascertained. Particularly, disruption of testosterone production by these chemicals can result in serious defects in male reproduction. Exposure to B[a]P reduced serum and intratesticular fluid testosterone levels in rats. Of note, the testosterone level reductions were accompanied by decreased steroidogenic acute regulatory protein (StAR) and 3β-hydevrepoxysteroid dehydevrepogenase isomerase (3β-HSD) expression in Leydig cells. B[a]P exposure can decrease epididymal sperm quality, possibly by disturbing the testosterone level. StAR may be a key steroidogenic protein that is targeted by B[a]P or other PAHs.
多环芳烃（PAHs）在空气中普遍存在，以挥发性和颗粒污染物的形式存在，是不完全燃烧的产物。大多数多环芳烃具有毒性、致突变性和/或致癌性。在多环芳烃中，苯并[a]芘（B[a]P）和二甲基苯并[a]蒽（DMBA）被怀疑是内分泌干扰物。睾丸是多环芳烃的重要靶器官，但对睾丸间质细胞类固醇生成的影响尚待确定。特别是，这些化学物质对睾酮生成的干扰会导致男性生殖出现严重缺陷。大鼠暴露于B[a]P会降低血清和睾丸内液体中的睾酮水平。值得注意的是，睾酮水平降低伴随着睾丸间质细胞中类固醇生成急性调节蛋白（StAR）和3β-羟基类固醇脱氢酶异构酶（3β-HSD）表达的减少。B[a]P暴露可能通过干扰睾酮水平而降低附睾精子质量。StAR可能是B[a]P或其他多环芳烃作用的关键类固醇生成蛋白。
你提供的原文中“hydevrepocarbons”“hydevrepoxysteroid”“hydevrepogenase”等词有误，可能影响理解，正确的应该是“hydrocarbons”“hydroxysteroid”“hydrogenase” ，以上译文是按照正确词汇翻译的。
