Bonkain Florence, Ena Graziella, Depierreux Michel, Debelle Frédéric D, Nortier Joëlle L
Departments of Nephrology.
Gynaecology.
NDT Plus. 2010 Feb;3(1):51-3. doi: 10.1093/ndtplus/sfp119. Epub 2009 Sep 3.
Glomerular diseases may occur as primary manifestation of cancer, especially in patients older than 60 years. Among glomerulopathies, membranous nephropathy is preferentially associated with respiratory and gastrointestinal tract adenocarcinomas, whereas minimal change disease is most often seen in haematological malignancies. Though breast cancer is one of the most frequent malignancies in women, paraneoplastic glomerular disease is rarely observed. We describe the case of a 79-year-old female patient who presented with nephrotic syndrome and renal failure. Breast cancer was found. Pathological studies of kidney and breast biopsy revealed a minimal change disease and an infiltrating ductal carcinoma, respectively.
肾小球疾病可能作为癌症的主要表现出现，尤其是在60岁以上的患者中。在肾小球病中，膜性肾病优先与呼吸道和胃肠道腺癌相关，而微小病变病最常见于血液系统恶性肿瘤。虽然乳腺癌是女性最常见的恶性肿瘤之一，但副肿瘤性肾小球疾病很少见。我们描述了一名79岁女性患者的病例，该患者表现为肾病综合征和肾衰竭。发现患有乳腺癌。肾脏和乳腺活检的病理研究分别显示为微小病变病和浸润性导管癌。
