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低补体血症性免疫复合物性肾小管间质性肾炎

Hypocomplementaemic immune complex tubulointerstitial nephritis.

作者信息

Gupta Alok, Jothy Serge, Somerville Peter, Zaltzman Jeffrey S

机构信息

Department of Nephrology.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto , Canada.

出版信息

NDT Plus. 2010 Feb;3(1):78-80. doi: 10.1093/ndtplus/sfp141. Epub 2009 Oct 7.

DOI:10.1093/ndtplus/sfp141
PMID:25949412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4421536/
Abstract

We report a rare cause of rapidly progressive renal failure associated with low complement, positive ANA but negative anti DS-DNA. A renal biopsy demonstrated tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane but glomerular sparing. A review of the literature and differential diagnosis are discussed.

摘要

我们报告了一例罕见的快速进展性肾衰竭病例，其伴有低补体、抗核抗体阳性但抗双链DNA阴性。肾活检显示为肾小管间质性肾炎，免疫球蛋白染色阳性，累及间质和肾小管基底膜，但肾小球未受累。本文还讨论了文献复习及鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/b8742ed77010/sfp141fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/daf3fca15a1d/sfp141fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/0e1426e7c1af/sfp141fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/b8742ed77010/sfp141fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/daf3fca15a1d/sfp141fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/0e1426e7c1af/sfp141fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c4d/4421536/b8742ed77010/sfp141fig3.jpg

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Hypocomplementaemic immune complex tubulointerstitial nephritis.低补体血症性免疫复合物性肾小管间质性肾炎
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引用本文的文献

1
IgG4-related disease should be considered in cases of hypocomplementemic immune-complex tubulointerstitial nephritis.低补体血症性免疫复合物性肾小管间质性肾炎病例应考虑IgG4相关性疾病。
NDT Plus. 2010 Jun;3(3):326. doi: 10.1093/ndtplus/sfq019. Epub 2010 Mar 26.
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Reply.回复。
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Diagnosis of IgG4-related tubulointerstitial nephritis.IgG4 相关肾小管间质性肾炎的诊断。

本文引用的文献

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Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome.肾小管间质性肾炎和葡萄膜炎综合征（TINU）：在理解一种难以捉摸的眼肾综合征方面向前迈进了一步。
Nephrol Dial Transplant. 2008 Apr;23(4):1095-7. doi: 10.1093/ndt/gfm940. Epub 2008 Feb 13.
2
Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis.
Nat Clin Pract Nephrol. 2007 Jan;3(1):50-8. doi: 10.1038/ncpneph0347.
3
Interstitial nephritis and high titers of PR3-ANCA: an unusual manifestation of ANCA-associated disease.
Clin Nephrol. 2005 Nov;64(5):383-6. doi: 10.5414/cnp64383.
4
J Am Soc Nephrol. 2011 Jul;22(7):1343-52. doi: 10.1681/ASN.2011010062. Epub 2011 Jun 30.
Predominant tubulointerstitial nephritis in a patient with systemic lupus nephritis.系统性红斑狼疮肾炎患者以肾小管间质性肾炎为主
Clin Exp Nephrol. 2005 Mar;9(1):79-84. doi: 10.1007/s10157-004-0338-3.
5
Idiopathic hypocomplementemic interstitial nephritis with extensive tubulointerstitial deposits.伴有广泛肾小管间质沉积物的特发性低补体血症性间质性肾炎。
Am J Kidney Dis. 2001 Feb;37(2):388-99. doi: 10.1053/ajkd.2001.21320.
6
Clinically significant and biopsy-documented renal involvement in primary Sjögren syndrome.原发性干燥综合征中具有临床意义且经活检证实的肾脏受累情况。
Medicine (Baltimore). 2000 Jul;79(4):241-9. doi: 10.1097/00005792-200007000-00005.
7
Acute interstitial nephritis with immune complex deposition and MHC class II antigen presentation along the tubular basement membrane.急性间质性肾炎伴免疫复合物沉积及沿肾小管基底膜的主要组织相容性复合体II类抗原呈递。
Nephrol Dial Transplant. 1999 Sep;14(9):2210-5. doi: 10.1093/ndt/14.9.2210.
8
Acute interstitial nephritis. A case characterized by increase in serum IgG, IgM, and IgE concentrations. Eosinophilia, and IgE deposition in renal tubules.急性间质性肾炎。一例以血清IgG、IgM和IgE浓度升高、嗜酸性粒细胞增多以及IgE在肾小管沉积为特征的病例。
Arch Intern Med. 1981 Apr;141(5):679-81. doi: 10.1001/archinte.141.5.679.
9
Acute renal failure due to ciprofloxacin.
Arch Intern Med. 1990 Oct;150(10):2187-9.