Gupta Alok, Jothy Serge, Somerville Peter, Zaltzman Jeffrey S
Department of Nephrology.
Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto , Canada.
NDT Plus. 2010 Feb;3(1):78-80. doi: 10.1093/ndtplus/sfp141. Epub 2009 Oct 7.
We report a rare cause of rapidly progressive renal failure associated with low complement, positive ANA but negative anti DS-DNA. A renal biopsy demonstrated tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane but glomerular sparing. A review of the literature and differential diagnosis are discussed.
我们报告了一例罕见的快速进展性肾衰竭病例,其伴有低补体、抗核抗体阳性但抗双链DNA阴性。肾活检显示为肾小管间质性肾炎,免疫球蛋白染色阳性,累及间质和肾小管基底膜,但肾小球未受累。本文还讨论了文献复习及鉴别诊断。