缺氧诱导因子-2α/肌醇1,4,5-三磷酸受体1轴：自然杀伤细胞介导的细胞溶解作用的新破坏者
HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysis.
作者信息
Messai Yosra, Noman Muhammad Zaeem, Hasmim Meriem, Escudier Bernard, Chouaib Salem
机构信息
INSERM U753; Gustave Roussy Cancer campus ; Villejuif, France.
Medical Oncology Department; Gustave Roussy Cancer Campus ; Villejuif, France.
出版信息
Oncoimmunology. 2015 Mar 6;4(2):e985951. doi: 10.4161/2162402X.2014.985951. eCollection 2015 Feb.
Abstract
We recently investigated the role of von Hippel-Lindau ( mutation and the subsequent induction of hypoxia-inducible factor 2α (HIF-2α) in the regulation of renal cell carcinoma (RCC) susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the resistance of -mutated RCC cell line 786-0 to NK-mediated lysis requires HIF-2α and ITPR1, a direct novel target of HIF-2α, through the activation of autophagy in target cells by NK-derived signals.
摘要
我们最近研究了冯·希佩尔-林道（von Hippel-Lindau）（VHLD）突变以及随后缺氧诱导因子2α（HIF-2α）的诱导在调节肾细胞癌（RCC）对自然杀伤（NK）细胞介导杀伤的易感性中的作用。我们证明，VHLD突变的RCC细胞系786-0对NK介导的裂解的抗性需要HIF-2α和ITPR（肌醇1,4,5-三磷酸受体1），ITPR是HIF-2α的一个直接新靶点，通过NK衍生信号激活靶细胞中的自噬来实现。
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