*Departments of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, TX †Departments of Pathology, University of Texas Medical Branch at Galveston, TX.
J Low Genit Tract Dis. 1999 Apr;3(2):73-6. doi: 10.1046/j.1526-0976.1999.08090.x.
We sought to correlate cervical and endometrial neoplasias with Papanicolaou (Pap) smears of atypical glandular cells of undetermined significance (AGUS) and to suggest management.
One hundred seventy-one patients with AGUS Pap smears were followed prospectively with colposcopy, biopsies, endocervical curettage, and endometrial biopsies.
One hundred twelve patients (65%) with AGUS Pap smears favoring reactive changes were found to harbor 13 preinvasive and invasive cervical squamous neoplasias and 1 ovarian sarcoma (total, 12.5% of patients with smears). Fifty-nine patients (35%) with AGUS Pap smears favoring neoplastic changes harbored 25 preinvasive and invasive squamous and glandular cervical and endometrial neoplasias (42.3%).
In the presence of an AGUS Pap smear favoring reactive changes, colposcopy, biopsies, and endocervical curettage should be performed. Endometrial biopsy should be added when AGUS Pap smear favors neoplasia.
我们旨在探讨巴氏涂片显示非典型腺细胞意义不明确（AGUS）与宫颈和子宫内膜肿瘤之间的相关性，并提出相应的处理建议。
对 171 例 AGUS 巴氏涂片患者进行前瞻性随访，包括阴道镜检查、活检、宫颈管搔刮和子宫内膜活检。
13 例宫颈鳞状上皮内瘤变和 1 例卵巢肉瘤（总发生率为 12.5%）被发现存在于 112 例（65%）AGUS 巴氏涂片提示反应性改变的患者中。59 例（35%）AGUS 巴氏涂片提示肿瘤性改变的患者中存在 25 例宫颈和子宫内膜的鳞状上皮和腺上皮的癌前病变和浸润性肿瘤（42.3%）。
对于 AGUS 巴氏涂片提示反应性改变的患者，应进行阴道镜检查、活检和宫颈管搔刮。当 AGUS 巴氏涂片提示肿瘤性改变时，应加做子宫内膜活检。
