Jaffe M J, Hommer D W, Caruso R C, Straw G M, de Monasterio F M
National Eye Institute, Bethesda, MD.
Retina. 1989;9(3):216-25.
Response/log I curves were obtained under conditions of dark-and light-adaptation in seven normal male volunteers. For each subject, a baseline electroretinogram (ERG) was recorded. In the same afternoon, a second ERG was obtained after 0.05 mg/kg diazepam, and a third ERG was recorded following 0.10 mg/kg diazepam. Under conditions of dark-adaptation, the following dose-dependent changes were identified: 1) Diazepam attenuated the rod b-wave peak amplitude and increased its implicit time; 2) The dark-adapted longer wavelength cone a-wave and 'blue cone' b-wave showed an increased implicit time; 3) All oscillatory potentials showed an increased implicit time. Under conditions of light-adaptation, dose-dependent decreases in peak amplitude and delays in implicit time were observed for the a- and b-waves. The effects of diazepam on the human ERG were more profound under conditions of light- than dark-adaptation.
在七名正常男性志愿者中，于暗适应和明适应条件下获取了反应/对数电流曲线。对每位受试者记录了一次基线视网膜电图（ERG）。在同一天下午，给予0.05mg/kg地西泮后记录第二次ERG，给予0.10mg/kg地西泮后记录第三次ERG。在暗适应条件下，识别出以下剂量依赖性变化：1）地西泮使视杆细胞b波峰值振幅衰减并使其潜伏时延长；2）暗适应时长波长视锥细胞a波和“蓝视锥细胞”b波的潜伏时增加；3）所有振荡电位的潜伏时均增加。在明适应条件下，观察到a波和b波的峰值振幅呈剂量依赖性降低且潜伏时延迟。地西泮对人体ERG的影响在明适应条件下比暗适应条件下更显著。
