Kyoi T, Yamamoto O, Ide Y, Ueda F, Kimura K
Research Laboratories, Nippon Shinyaku Co. Ltd., Kyoto, Japan.
Scand J Gastroenterol Suppl. 1989;162:182-5. doi: 10.3109/00365528909091156.
We examined the antisecretory and anti-ulcer effects of ALE-36 in rats. ALE-36 (3-30 mg/kg) dose-dependently inhibited gastric acid secretion in pylorus-ligated rats. However, the agent apparently increased the volume of gastric juice, and the Na+ and Cl- ion outputs. These changes were almost completely prevented by pretreatment with indomethacin, suggesting that endogenous prostaglandins in the gastric mucosa mediated the changes. Pretreatment with ALE-36 (3-30 mg/kg) inhibited the development of stress-, aspirin-, and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcers. Repeated administration of ALE-36 significantly accelerated the healing of gastric ulcers induced by thermocautery.
