Pedroso Célia, Martins Isabel, Palma Fátima, Machado Ana Isabel
Department of Gynecology, Maternidade Alfredo da Costa, Centro Hospitalar Lisboa Central, Lisboa, Portugal.
Department of Obstetrics, Maternidade Alfredo da Costa, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
BMJ Case Rep. 2015 May 7;2015:bcr2014206256. doi: 10.1136/bcr-2014-206256.
Nexplanon (Schering-Plough Limited/Merck Sharp & Dohme Limited (MSD)) is a long active reversible contraceptive method that provides effective contraception for 3 years. It consists of a single, flexible, rod-shaped implant, containing 68 mg etonogestrel. It is 4 cm long, consists of an ethylene vinyl acetate copolymer, a non-absorbable material, and also contains 15 mg of barium sulfate, which makes it visible by X-ray. We describe a case of a 39-year-old woman who experienced a local reaction to the barium sulfate in Nexplanon. She was given medical treatment, but only the removal of the implant resolved the symptoms. After removal there was gradual improvement and 72 h later the patient was asymptomatic. Allergic reaction to barium sulfate is extremely rare: until now, there have only been two cases associated with Nexplanon described in the literature.
依伴侬（先灵葆雅有限公司/默克雪兰诺有限公司（默克公司））是一种长效可逆的避孕方法，可提供3年的有效避孕效果。它由一根单一的、柔韧的棒状植入物组成，含有68毫克依托孕烯。它长4厘米，由乙烯-醋酸乙烯共聚物（一种不可吸收材料）制成，还含有15毫克硫酸钡，这使得它在X射线下可见。我们描述了一例39岁女性对依伴侬中的硫酸钡发生局部反应的病例。她接受了药物治疗，但只有取出植入物才能缓解症状。取出后症状逐渐改善，72小时后患者无症状。对硫酸钡的过敏反应极为罕见：到目前为止，文献中仅描述了两例与依伴侬相关的病例。
