Welch Brandon M, Rodriguez-Loya Salvador, Eilbeck Karen, Kawamoto Kensaku
Medical University of South Carolina, Charleston, SC ; University of Utah, Salt Lake City, UT.
University of Sussex, East Sussex, United Kingdom.
AMIA Annu Symp Proc. 2014 Nov 14;2014:1188-97. eCollection 2014.
Whole genome sequence (WGS) information could soon be routinely available to clinicians to support the personalized care of their patients. At such time, clinical decision support (CDS) integrated into the clinical workflow will likely be necessary to support genome-guided clinical care. Nevertheless, developing CDS capabilities for WGS information presents many unique challenges that need to be overcome for such approaches to be effective. In this manuscript, we describe the development of a prototype CDS system that is capable of providing genome-guided CDS at the point of care and within the clinical workflow. To demonstrate the functionality of this prototype, we implemented a clinical scenario of a hypothetical patient at high risk for Lynch Syndrome based on his genomic information. We demonstrate that this system can effectively use service-oriented architecture principles and standards-based components to deliver point of care CDS for WGS information in real-time.
全基因组序列（WGS）信息可能很快就能常规地提供给临床医生，以支持对患者的个性化护理。届时，整合到临床工作流程中的临床决策支持（CDS）可能对于支持基因组引导的临床护理是必要的。然而，为WGS信息开发CDS功能存在许多独特的挑战，要使这些方法有效就需要克服这些挑战。在本手稿中，我们描述了一个原型CDS系统的开发，该系统能够在护理点和临床工作流程中提供基因组引导的CDS。为了演示这个原型的功能，我们基于一名假设的林奇综合征高危患者的基因组信息实施了一个临床场景。我们证明，该系统可以有效地使用面向服务的架构原则和基于标准的组件，实时为WGS信息提供护理点CDS。
