医疗补助患者中基于数据驱动的口服降糖药依从性测量方法的比较
A Comparison of Data Driven-based Measures of Adherence to Oral Hypoglycemic Agents in Medicaid Patients.
作者信息
Zhu Vivienne J, Tu Wanzhu, Rosenman Marc B, Overhage J Marc
机构信息
Regenstrief Institute, IN.
Siemens Healthcare, Malvern, PA.
出版信息
AMIA Annu Symp Proc. 2014 Nov 14;2014:1294-301. eCollection 2014.
Abstract
We evaluated and compared different methods for measuring adherence to Oral Antihyperglycemic Agents (OHA), based on the correlation between these measures and glycated hemoglobin A1C (HbA1c) levels in Medicaid patients with Type 2 diabetes. An observational sample of 831 Medicaid patients with Type 2 diabetes who had HbA1c test results recorded between January 1, 2001 and December 31, 2005 was identified in the Indiana Network of Patient Care (INPC). OHA adherence was measured by medication possession ratio (MPR), proportion of days covered (PDC), and the number of gaps (GAP) for 3, 6, and 12-month intervals prior to the HbA1c test date. All three OHA adherence measurements showed consistent and significant correlation with HbA1c level. The 6-month PDC showed the strongest association with HbA1c levels in both unadjusted (-1.07, P<0.0001) and adjusted (-1.12, P<0.0001) models.
摘要
我们基于这些测量方法与医疗补助计划中2型糖尿病患者糖化血红蛋白A1C（HbA1c）水平之间的相关性，评估并比较了测量口服降糖药（OHA）依从性的不同方法。在印第安纳州患者护理网络（INPC）中，确定了一个观察样本，其中包括831名在2001年1月1日至2005年12月31日期间有HbA1c检测结果记录的医疗补助计划2型糖尿病患者。通过药物持有率（MPR）、覆盖天数比例（PDC）以及在HbA1c检测日期前3个月、6个月和12个月间隔的用药间断次数（GAP）来衡量OHA依从性。所有这三种OHA依从性测量方法均与HbA1c水平显示出一致且显著的相关性。在未调整模型（-1.07，P<0.0001）和调整模型（-1.12，P<0.0001）中，6个月的PDC与HbA1c水平的关联最强。
相似文献
1
A Comparison of Data Driven-based Measures of Adherence to Oral Hypoglycemic Agents in Medicaid Patients.医疗补助患者中基于数据驱动的口服降糖药依从性测量方法的比较
AMIA Annu Symp Proc. 2014 Nov 14;2014:1294-301. eCollection 2014.
2
Race and medication adherence and glycemic control: findings from an operational health information exchange.种族与药物依从性及血糖控制：来自一项实用健康信息交换的研究结果
AMIA Annu Symp Proc. 2011;2011:1649-57. Epub 2011 Oct 22.
3
Assessment of basal insulin adherence using 2 methodologies among Texas Medicaid enrollees with type 2 diabetes.采用 2 种方法评估德克萨斯州医疗补助计划 2 型糖尿病患者的基础胰岛素依从性。
J Manag Care Spec Pharm. 2020 Nov;26(11):1434-1444. doi: 10.18553/jmcp.2020.26.11.1434.
4
Impact on glycated haemoglobin of a biological response-based measure of medication adherence.基于生物学反应的药物依从性测量对糖化血红蛋白的影响。
Diabetes Obes Metab. 2015 Sep;17(9):843-8. doi: 10.1111/dom.12476. Epub 2015 May 20.
5
Metformin adherence in patients with type 2 diabetes and its association with glycated haemoglobin levels.二甲双胍在 2 型糖尿病患者中的依从性及其与糖化血红蛋白水平的关系。
J Prim Health Care. 2020 Dec;12(4):318-326. doi: 10.1071/HC20043.
6
Predictive Validity of Self-Reported Measures of Adherence to Noninsulin Antidiabetes Medication against Control of Glycated Hemoglobin Levels.自我报告的非胰岛素抗糖尿病药物依从性测量对糖化血红蛋白水平控制的预测效度。
Can J Diabetes. 2016 Feb;40(1):58-65. doi: 10.1016/j.jcjd.2015.06.008. Epub 2015 Oct 23.
7
Retrospective Study on the Impact of Adherence in Achieving Glycemic Goals in Type 2 Diabetes Mellitus Patients Receiving Canagliflozin.接受卡格列净治疗的2型糖尿病患者依从性对实现血糖目标影响的回顾性研究
Adv Ther. 2017 Apr;34(4):937-953. doi: 10.1007/s12325-017-0500-4. Epub 2017 Mar 1.
8
Adherence to oral antidiabetic medications in the pediatric population with type 2 diabetes: a retrospective database analysis.2 型糖尿病儿科患者口服抗糖尿病药物的依从性：回顾性数据库分析。
Clin Ther. 2012 Mar;34(3):712-9. doi: 10.1016/j.clinthera.2012.01.028. Epub 2012 Feb 28.
9
The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy.新起始接受二甲双胍治疗的糖尿病患者初始依从性及随后依从性变化与 HbA1c 的变化。
J Diabetes Res. 2016;2016:9687815. doi: 10.1155/2016/9687815. Epub 2016 Aug 7.
10
HBA1C CONTROL AND COST-EFFECTIVENESS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS INITIATED ON CANAGLIFLOZIN OR A GLUCAGON-LIKE PEPTIDE 1 RECEPTOR AGONIST IN A REAL-WORLD SETTING.在真实世界环境中，接受坎格列净或胰高血糖素样肽-1 受体激动剂治疗的 2 型糖尿病患者的 HBA1C 控制和成本效益。
Endocr Pract. 2018 Mar;24(3):273-287. doi: 10.4158/EP-2017-0066.
引用本文的文献
1
Suitability of Measures of Pharmacy-Based Medication Adherence for Routine Clinical Use Among Patients with Chronic Diseases: A Systematic Review.基于药房的药物依从性测量方法在慢性病患者常规临床应用中的适用性：一项系统评价
Patient Prefer Adherence. 2025 Jan 30;19:265-278. doi: 10.2147/PPA.S492461. eCollection 2025.
2
Association of Medication Adherence With HbA1c Control Among American Indian Adults With Type 2 Diabetes Using Tribal Health Services.美国印第安人 2 型糖尿病患者使用部落卫生服务时，药物治疗依从性与 HbA1c 控制的相关性。
Diabetes Care. 2023 Jun 1;46(6):1245-1251. doi: 10.2337/dc22-1885.
3
Impact of adherence goal awareness intervention on PDC in various settings: Does awareness help modify medication-taking behavior?依从性目标意识干预对不同环境下持续药物治疗率的影响：意识是否有助于改变服药行为？
Explor Res Clin Soc Pharm. 2021 Sep 23;4:100072. doi: 10.1016/j.rcsop.2021.100072. eCollection 2021 Dec.
4
Accurate Medication Adherence Measurement Using Administrative Data for Frequently Hospitalized Patients.使用管理数据对频繁住院患者进行准确的药物依从性测量。
Hosp Pharm. 2021 Oct;56(5):451-461. doi: 10.1177/0018578720918550. Epub 2020 Jun 2.
5
Wirelessly Observed Therapy to Optimize Adherence and Target Interventions for Oral Hepatitis C Treatment: Observational Pilot Study.无线观测疗法优化口服丙型肝炎治疗的依从性及靶向干预：观察性试点研究
J Med Internet Res. 2020 Feb 24;22(2):e15532. doi: 10.2196/15532.
6
Racial and Geographic Disparities in Endocrine Therapy Adherence Among Younger Breast Cancer Survivors.年轻乳腺癌幸存者内分泌治疗依从性的种族和地域差异。
Am J Clin Oncol. 2020 Jul;43(7):504-509. doi: 10.1097/COC.0000000000000696.
7
The impact of depression medications on oral antidiabetic drug adherence in patients with diabetes and depression.抑郁药物对伴发抑郁的糖尿病患者口服抗糖尿病药物依从性的影响。
J Diabetes Complications. 2018 May;32(5):492-500. doi: 10.1016/j.jdiacomp.2017.12.008. Epub 2017 Dec 27.
本文引用的文献
1
Determinants and consequences of insulin initiation for type 2 diabetes in France: analysis of the National Health and Wellness Survey.法国2型糖尿病胰岛素起始治疗的决定因素及后果：国民健康与生活方式调查分析
Patient Prefer Adherence. 2013 Oct 4;7:1007-23. doi: 10.2147/PPA.S51299. eCollection 2013.
2
Predictors of medication adherence in patients with type 2 diabetes mellitus.2 型糖尿病患者药物治疗依从性的预测因素。
Curr Med Res Opin. 2013 Oct;29(10):1275-86. doi: 10.1185/03007995.2013.821056. Epub 2013 Jul 23.
3
Medication nonadherence in diabetes: longitudinal effects on costs and potential cost savings from improvement.糖尿病患者用药不依从：对成本的纵向影响及改善的潜在成本节约。
Diabetes Care. 2012 Dec;35(12):2533-9. doi: 10.2337/dc12-0572. Epub 2012 Aug 21.
4
Prescribing history to identify candidates for chronic condition medication adherence promotion.通过开药记录来确定慢性病药物治疗依从性提升的候选对象。
Stud Health Technol Inform. 2011;169:634-8.
5
Racial differences in glycemic markers: a cross-sectional analysis of community-based data.种族间血糖指标的差异：基于社区数据的横断面分析。
Ann Intern Med. 2011 Mar 1;154(5):303-9. doi: 10.7326/0003-4819-154-5-201103010-00004.
6
Measurements of medication adherence in diabetic patients with poorly controlled HbA(1c).测量 HbA(1c)控制不佳的糖尿病患者的药物依从性。
Diabet Med. 2010 Feb;27(2):210-6. doi: 10.1111/j.1464-5491.2009.02898.x.
7
Predictors of medication nonadherence among patients with diabetes in Medicare Part D programs: a retrospective cohort study.医疗保险处方药计划中糖尿病患者药物不依从的预测因素：一项回顾性队列研究。
Clin Ther. 2009 Oct;31(10):2178-88; discussion 2150-1. doi: 10.1016/j.clinthera.2009.10.002.
8
Medication adherence: its importance in cardiovascular outcomes.药物依从性：其在心血管结局中的重要性。
Circulation. 2009 Jun 16;119(23):3028-35. doi: 10.1161/CIRCULATIONAHA.108.768986.
9
Comparison of methods to assess medication adherence and classify nonadherence.评估药物依从性及对不依从进行分类的方法比较。
Ann Pharmacother. 2009 Mar;43(3):413-22. doi: 10.1345/aph.1L496. Epub 2009 Mar 3.
10
Comparison of various measures for assessing medication refill adherence using prescription data.使用处方数据评估药物续方依从性的各种方法比较。
Pharmacoepidemiol Drug Saf. 2009 Feb;18(2):159-65. doi: 10.1002/pds.1698.
Zotero 插件