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脊柱原发性尤因肉瘤伴截瘫的罕见表现:一例报告

Unusual Presentation of a Primary Ewing's Sarcoma of the Spine with Paraplegia: A Case Report.

作者信息

Kannan Karthik Kailash, Sundarapandian Rajkumar Jayachandran, Surulivel Vignesh Jayabalan

机构信息

Chief of Spine Surgery, Hindu Mission Hospital, Chief-Division of Spine Surgery, Sri Ramachandra University , Chennai, India .

Associate Consultant, Spine Surgeon, Hindu Mission Hospital , India .

出版信息

J Clin Diagn Res. 2015 Mar;9(3):RD01-3. doi: 10.7860/JCDR/2015/11647.5663. Epub 2015 Mar 1.

Abstract

Ewing's sarcoma is a primary malignancy of the bone affecting individuals in the second decade of life. Primary sarcomas of the spine are rare and the occurrence of Primary Ewing's sarcoma in the spine is very rare. Ewing's sarcoma occurring in the spine is divided into two types, Ewing's sarcoma of sacral spine which are very aggressive with poor prognosis and Ewing's sarcoma of the non sacral spine which is an extremely rare occurrence. Patient may present with neurological deficit when the tumour extends into the spinal canal causing spinal cord compression. Magnetic resonance imaging (MRI) is very sensitive in diagnosing the tumour and defining the extent of the tumour. Here we report an 18-year-old boy who presented with back pain and complete paraplegia of two months duration. The MRI gave a differential diagnosis of infective pathology due to the fluid collection in the paraspinal region, followed by primary malignancy as the second diagnosis. Patient underwent posterior spinal decompression and stabilization, and intaoperatively there was significant collection of pus whose culture showed no growth. The histopathology and immunohistochemistry studies confirmed the diagnosis of Ewing's sarcoma and patient was started on combination chemotherapy and radiotherapy.

摘要

尤因肉瘤是一种原发性骨恶性肿瘤,好发于第二个十年的人群。原发性脊柱肉瘤罕见,而原发性尤因肉瘤发生于脊柱则极为罕见。发生于脊柱的尤因肉瘤分为两种类型,骶骨尤因肉瘤侵袭性很强,预后较差,非骶骨尤因肉瘤则极其罕见。当肿瘤延伸至椎管导致脊髓受压时,患者可能会出现神经功能缺损。磁共振成像(MRI)在诊断肿瘤及确定肿瘤范围方面非常敏感。在此,我们报告一名18岁男孩,他出现背痛并伴有持续两个月的完全性截瘫。MRI因椎旁区域有积液而给出感染性病变的鉴别诊断,其次诊断为原发性恶性肿瘤。患者接受了后路脊柱减压及固定手术,术中发现有大量脓液,其培养无生长。组织病理学和免疫组织化学研究证实为尤因肉瘤诊断,患者开始接受联合化疗和放疗。

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