用于胃病变内镜监测的计算机模拟活检标记系统：一项初步研究。

Computer-simulated biopsy marking system for endoscopic surveillance of gastric lesions: a pilot study.

作者信息

Hu Weiling, Wang Bin, Sun Leimin, Chen Shujie, Wang Liangjing, Wang Kan, Wu Jiaguo, Kim John J, Liu Jiquan, Dai Ning, Duan Huilong, Si Jianmin

机构信息

Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.

College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China ; Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China.

出版信息

Biomed Res Int. 2015;2015:197270. doi: 10.1155/2015/197270. Epub 2015 Apr 14.

DOI:10.1155/2015/197270

PMID:25954747

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4411451/

Abstract

Endoscopic tattoo with India ink injection for surveillance of premalignant gastric lesions is technically cumbersome and may not be durable. The aim of the study is to evaluate the accuracy of a novel, computer-simulated biopsy marking system (CSBMS) developed for the endoscopic marking of gastric lesions. Twenty-five patients with history of gastric intestinal metaplasia received both CSBMS-guided marking and India ink injection in five points in the stomach at index endoscopy. A second endoscopy was performed at three months. Primary outcome was accuracy of CSBMS (distance between CSBMS probe-guided site and tattoo site measured by CSBMS). The mean accuracy of CSBMS at angularis was 5.3 ± 2.2 mm, antral lesser curvature 5.7 ± 1.4 mm, antral greater curvature 6.1 ± 1.1 mm, antral anterior wall 6.9 ± 1.6 mm, and antral posterior wall 6.9 ± 1.6 mm. CSBMS (2.3 ± 0.9 versus 12.5 ± 4.6 seconds; P = 0.02) required less procedure time compared to endoscopic tattooing. No adverse events were encountered. CSBMS accurately identified previously marked gastric sites by endoscopic tattooing within 1 cm on follow-up endoscopy.

摘要

用于监测胃癌前病变的内镜下印度墨水注射纹身技术操作繁琐，且效果可能不持久。本研究的目的是评估一种为内镜下标记胃部病变而开发的新型计算机模拟活检标记系统（CSBMS）的准确性。25例有胃肠化生病史的患者在初次内镜检查时，在胃的五个部位接受了CSBMS引导下的标记和印度墨水注射。三个月后进行了第二次内镜检查。主要结局指标是CSBMS的准确性（通过CSBMS测量CSBMS探头引导部位与纹身部位之间的距离）。CSBMS在胃角的平均准确性为5.3±2.2毫米，胃窦小弯处为5.7±1.4毫米，胃窦大弯处为6.1±1.1毫米，胃窦前壁为6.9±1.6毫米，胃窦后壁为6.9±1.6毫米。与内镜纹身相比，CSBMS所需的操作时间更少（2.3±0.9秒对12.5±4.6秒；P=0.02）。未发生不良事件。在随访内镜检查中，CSBMS能准确识别先前经内镜纹身标记的胃部部位，误差在1厘米以内。