Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Structure. 2015 May 5;23(5):803-804. doi: 10.1016/j.str.2015.04.012.
BAR domains bend membranes by imposing their curved shape. In this issue, Isas et al. show the structural differences in the interaction of the BAR domain protein amphiphysin with vesicles and tubes. They find that superficial interactions lead to vesicles, whereas more penetrating interactions of a more crowded protein lead to tubes.
BAR 结构域通过施加其弯曲形状来弯曲膜。在本期杂志中，Isas 等人展示了 BAR 结构域蛋白 amphiphysin 与囊泡和管状结构相互作用的结构差异。他们发现，浅表面相互作用导致形成囊泡，而更深的、更拥挤的蛋白质的相互作用则导致管状结构的形成。
