可视化过氧-二铁(III)中间物的美。
The Beauty of a Visualized Peroxo-diiron(III) Intermediate.
机构信息
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Republic of Singapore.
出版信息
Structure. 2015 May 5;23(5):805-806. doi: 10.1016/j.str.2015.04.010.
PMID:25955100
Abstract
Deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are essential for hypusination of eukaryotic translation initiation factor 5A (eIF-5A). In this issue, Han et al. use X-ray crystallograpy and UV/Vis and Mössbauer spectroscopy to provide insights into the fundamental mechanism of the hypusination of eIF-5A and a peroxo intermediate state.
摘要
脱羟鸟苷酸合成酶（DHS）和脱羟鸟苷酸羟化酶（DOHH）对于真核翻译起始因子 5A（eIF-5A）的脱羟鸟苷酸化是必不可少的。在本期杂志中，Han 等人利用 X 射线晶体学以及紫外/可见和穆斯堡尔光谱学，深入了解了 eIF-5A 脱羟鸟苷酸化的基本机制和过氧中间态。
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