Mic10寡聚化促使线粒体嵴缢缩。
Mic10 Oligomerization Pinches off Mitochondrial Cristae.
作者信息
Milenkovic Dusanka, Larsson Nils-Göran
机构信息
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
出版信息
Cell Metab. 2015 May 5;21(5):660-1. doi: 10.1016/j.cmet.2015.04.020.
Abstract
The mitochondrial contact site and cristae organizing system (MICOS) complex is essential for normal mitochondria biogenesis and morphology. In this issue, Bohnert et al. (2015) and Barbot et al. (2015) demonstrate that a MICOS core subunit, Mic10, is crucial for mitochondrial cristae formation by forming oligomers at the cristae junctions.
摘要
线粒体接触位点与嵴组织系统（MICOS）复合物对于正常的线粒体生物发生和形态至关重要。在本期中，博纳特等人（2015年）以及巴尔博特等人（2015年）证明，MICOS核心亚基Mic10通过在嵴连接处形成寡聚体，对线粒体嵴的形成至关重要。
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