Gozes Illana
Biol Chem. 2016 Mar;397(3):177-84. doi: 10.1515/hsz-2015-0152.
Fifteen years ago we discovered activity-dependent neuroprotective protein (ADNP), and showed that it is essential for brain formation/function. Our protein interaction studies identified ADNP as a member of the chromatin remodeling complex, SWI/SNF also associated with alternative splicing of tau and prediction of tauopathy. Recently, we have identified cytoplasmic ADNP interactions with the autophagy regulating microtubule-associated protein 1 light chain 3 (LC3) and with microtubule end-binding (EB) proteins. The ADNP-EB-binding SIP domain is shared with the ADNP snippet drug candidate, NAPVSIPQ termed NAP (davunetide). Thus, we identified a precise target for ADNP/NAP (davunetide) neuroprotection toward improved drug development.
15年前，我们发现了活性依赖的神经保护蛋白（ADNP），并表明它对大脑的形成/功能至关重要。我们的蛋白质相互作用研究确定ADNP是染色质重塑复合体SWI/SNF的成员，该复合体也与tau蛋白的可变剪接及tau蛋白病的预测有关。最近，我们确定了细胞质中的ADNP与自噬调节微管相关蛋白1轻链3（LC3）以及微管末端结合（EB）蛋白之间的相互作用。ADNP与EB结合的SIP结构域与ADNP片段药物候选物NAPVSIPQ（称为NAP，即达武奈肽）相同。因此，我们确定了ADNP/NAP（达武奈肽）神经保护作用的精确靶点，以促进药物开发。
