Isiordia-Espinoza Mario Alberto, Zapata-Morales Juan Ramón, Castañeda-Santana Demian Ismael, de la Rosa-Coronado Maximiliano, Aragon-Martinez Othoniel Hugo
Departamento de Farmacología, Facultad de Odontología Mexicali, Universidad Autónoma de Baja California, Mexicali, 21040, México.
Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, 36050, México.
Drug Dev Res. 2015 May;76(3):152-6. doi: 10.1002/ddr.21251. Epub 2015 May 8.
The aim of this study was to evaluate the interaction between tramadol and parecoxib in the orofacial formalin test. Tramadol (10, 31.6, 56, and 100 mg/kg ip) or parecoxib (31.6, 56, 100, and 178 mg/kg ip) were administered 10 min before formalin (2.5%) injection into the upper lip to characterize the dose-response curve of each individual drug in the orofacial pain test in mice. Once the dose-response curve of each drug was obtained, an experimental effective dose 50 (ED50 ) value was determined for each drug. The tramadol-parecoxib combination was evaluated in four different groups of animals. The isobolographic analysis and the interaction index were used to evaluate the nature of interaction between both drugs. The isobologram and the interaction index showed increased in the antinociceptive effect of the combination. The tramadol-parecoxib combination produces a synergism in the second phase of the orofacial formalin test.
本研究的目的是评估曲马多与帕瑞昔布在口腔福尔马林试验中的相互作用。在向小鼠上唇注射2.5%福尔马林前10分钟，腹腔注射曲马多（10、31.6、56和100mg/kg）或帕瑞昔布（31.6、56、100和178mg/kg），以确定每种药物在小鼠口腔疼痛试验中的剂量反应曲线。一旦获得每种药物的剂量反应曲线，就为每种药物确定实验性半数有效剂量（ED50）值。在四组不同的动物中评估曲马多-帕瑞昔布组合。采用等效应线图分析和相互作用指数来评估两种药物之间相互作用的性质。等效应线图和相互作用指数显示该组合的镇痛作用增强。曲马多-帕瑞昔布组合在口腔福尔马林试验的第二阶段产生协同作用。
