Moiseev S V, Semenkova E N, Shatkovskiĭ N P
Ter Arkh. 1989;61(9):79-81.
As many as 60 patients with hypereosinophilia of different genesis were examined. 40 of them manifested the clinical (congestive heart failure in 6, tachycardia in 10, cardialgias in 3, murmur in the heart in 13, pericardial murmur in 3) and/or ECG signs (disorders of repolarization in 25, His bundle block in 4, rhythm disorders in 7, pathologic Q waves in 2) of heart injury. In 15 out of the 20 examined, the echocardiography data corresponded to the dilated pattern of heart injury despite the fact that the changes in contractile function of the left ventricle were less appreciable than in 28 patients with dilated cardiomyopathy. In 2 patients who died (one from congestive heart failure and one from anaphylactic shock) the presence of endomyocardial fibrosis with heart dilatation was confirmed on postmortem examination. One female patient with right ventricular failure manifested the characteristic signs of isolated injury to the right ventricle. In 3 patients, the endocardium appeared thickened. None of the cases showed the signs of restrictive heart injury. The data obtained indicate that hypereosinophilia may be one of the etiologic factors of dilated cardiomyopathy.
对多达60例不同病因的嗜酸性粒细胞增多症患者进行了检查。其中40例表现出心脏损伤的临床症状（6例出现充血性心力衰竭，10例心动过速，3例心前区疼痛，13例心脏杂音，3例心包杂音）和/或心电图征象（25例复极异常，4例希氏束阻滞，7例心律失常，2例病理性Q波）。在接受检查的20例患者中，有15例的超声心动图数据符合心脏损伤的扩张型模式，尽管左心室收缩功能的变化不如28例扩张型心肌病患者明显。在2例死亡患者（1例死于充血性心力衰竭，1例死于过敏性休克）中，尸检证实存在心内膜纤维化伴心脏扩张。1例右心室衰竭的女性患者表现出右心室孤立损伤的特征性征象。3例患者的心内膜增厚。所有病例均未显示限制性心脏损伤的征象。所获得的数据表明，嗜酸性粒细胞增多症可能是扩张型心肌病的病因之一。
