Alli Elizabeth, Ford James M
Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA.
Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA; Stanford University School of Medicine, Department of Genetics, 269 Campus Drive, Stanford, CA 93405, USA.
DNA Repair (Amst). 2015 Aug;32:165-171. doi: 10.1016/j.dnarep.2015.04.028. Epub 2015 May 1.
Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.
自发现以来，BRCA1肿瘤抑制因子已被证明在多种DNA损伤反应途径中发挥作用。在此，我们将综述BRCA1在碱基切除DNA修复中的作用，并强调其临床意义。
