乳腺癌1号基因（BRCA1）：超越双链断裂修复

BRCA1: Beyond double-strand break repair.

作者信息

Alli Elizabeth, Ford James M

机构信息

Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA.

Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA; Stanford University School of Medicine, Department of Genetics, 269 Campus Drive, Stanford, CA 93405, USA.

出版信息

DNA Repair (Amst). 2015 Aug;32:165-171. doi: 10.1016/j.dnarep.2015.04.028. Epub 2015 May 1.

DOI:10.1016/j.dnarep.2015.04.028

PMID:25956865

Abstract

Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.

摘要

自发现以来，BRCA1肿瘤抑制因子已被证明在多种DNA损伤反应途径中发挥作用。在此，我们将综述BRCA1在碱基切除DNA修复中的作用，并强调其临床意义。