Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia; School of Computer Science and Engineering, UNSW Sydney, NSW 2052, Australia.
CSIRO, North Ryde NSW 1670, Australia.
Cell. 2015 May 7;161(4):948-948.e1. doi: 10.1016/j.cell.2015.04.041.
The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.
胰岛素/IGF1 信号通路（ISP）在长期健康中起着至关重要的作用。该通路的一些干扰与 2 型糖尿病等疾病有关；其他干扰则延长了线虫、果蝇和小鼠的寿命。ISP 调节许多生物过程，包括能量储存、细胞凋亡、转录和细胞内稳态。这种调节涉及到蛋白质磷酸化网络中时间事件的精确重布线。如需查看此增强型 SnapShot 的动画版本，请访问 http://www.cell.com/cell/enhanced/odonoghue。
