Tessier Sophie, Lambert Andréane, Chicoine Marjolaine, Scherzer Peter, Soulières Isabelle, Godbout Roger
Sleep Laboratory & Clinic, Hôpital Rivière-des-Prairies, Montréal, Québec, Canada; Centre de Recherche, Hôpital Rivière-des-Prairies, Montréal, Québec, Canada; Centre de Recherche, Institut Universitaire en Santé Mentale de Montréal, Montréal, Québec, Canada.
Department of Psychology, Université du Québec à Montréal, Montréal, Québec, Canada.
Int J Psychophysiol. 2015 Jul;97(1):58-65. doi: 10.1016/j.ijpsycho.2015.05.003. Epub 2015 May 8.
The relationship between intelligence measures and 2 EEG measures of non-rapid eye movement sleep, sleep spindles and Sigma activity, was examined in 13 typically-developing (TD) and 13 autistic children with normal IQ and no complaints of poor sleep. Sleep spindles and Sigma EEG activity were computed for frontal (Fp1, Fp2) and central (C3, C4) recording sites. Time in stage 2 sleep and IQ was similar in both groups. Autistic children presented less spindles at Fp2 compared to the TD children. TD children showed negative correlation between verbal IQ and sleep spindle density at Fp2. In the autistic group, verbal and full-scale IQ scores correlated negatively with C3 sleep spindle density. The duration of sleep spindles at Fp1 was shorter in the autistic group than in the TD children. The duration of sleep spindles at C4 was positively correlated with verbal IQ only in the TD group. Fast Sigma EEG activity (13.25-15.75 Hz) was lower at C3 and C4 in autistic children compared to the TD children, particularly in the latter part of the night. Only the TD group showed positive correlation between performance IQ and latter part of the night fast Sigma activity at C4. These results are consistent with a relationship between EEG activity during sleep and cognitive processing in children. The difference between TD and autistic children could derive from dissimilar cortical organization and information processing in these 2 groups.
对13名发育正常（TD）儿童和13名智商正常且无睡眠问题主诉的自闭症儿童，研究了智力测量与非快速眼动睡眠的两种脑电图测量指标（睡眠纺锤波和西格玛活动）之间的关系。计算了额叶（Fp1、Fp2）和中央（C3、C4）记录部位的睡眠纺锤波和西格玛脑电图活动。两组儿童的2期睡眠时间和智商相似。与TD儿童相比，自闭症儿童在Fp2部位的纺锤波较少。TD儿童的言语智商与Fp2部位的睡眠纺锤波密度呈负相关。在自闭症组中，言语智商和全量表智商得分与C3部位的睡眠纺锤波密度呈负相关。自闭症组在Fp1部位的睡眠纺锤波持续时间比TD儿童短。仅在TD组中，C4部位的睡眠纺锤波持续时间与言语智商呈正相关。与TD儿童相比，自闭症儿童在C3和C4部位的快速西格玛脑电图活动（13.25 - 15.75赫兹）较低，尤其是在夜间后期。仅TD组在C4部位的操作智商与夜间后期快速西格玛活动呈正相关。这些结果与儿童睡眠期间的脑电图活动和认知加工之间的关系一致。TD儿童和自闭症儿童之间的差异可能源于这两组不同的皮质组织和信息加工方式。
