对磺基杯[n]芳烃作为分子通过Caco-2模型肠膜的选择性激活剂。
para-Sulphonato-calix[n]arenes as selective activators for the passage of molecules across the Caco-2 model intestinal membrane.
作者信息
Roka Eszter, Vecsernyes Miklos, Bacskay Ildiko, Félix Caroline, Rhimi Moez, Coleman Anthony W, Perret Florent
机构信息
University of Debrecen, Department of Pharmaceutical Technology, Debrecen, Hungary.
出版信息
Chem Commun (Camb). 2015 Jun 7;51(45):9374-6. doi: 10.1039/c5cc01777g.
PMID:25958962
Abstract
The passage of Lucifer Yellow across the Caco-2 intestinal model membrane has been studied for the para-sulphonato-calix[n]arenes, the results show that para-sulphonato-calix[4]arene and para-sulphonato-calix[8]arene activate membrane passage when used simultaneously with a transport probe, Lucifer Yellow, whereas para-sulphonato-calix[6]arene has no effect.
摘要
已针对对磺基杯[n]芳烃研究了荧光素黄透过Caco-2肠模型膜的情况，结果表明，对磺基杯[4]芳烃和对磺基杯[8]芳烃在与转运探针荧光素黄同时使用时会激活膜通透，而对磺基杯[6]芳烃则无作用。
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