肿瘤相关抗原或抗 TAA 自身抗体作为卵巢癌诊断的生物标志物：系统评价与荟萃分析。
Tumor associated antigens or anti-TAA autoantibodies as biomarkers in the diagnosis of ovarian cancer: a systematic review with meta-analysis.
机构信息
Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
出版信息
Expert Rev Mol Diagn. 2015 Jun;15(6):829-52. doi: 10.1586/14737159.2015.1035713. Epub 2015 May 9.
OBJECTIVE
This systematic review aims to outline and summarize known tumor-associated antigens (TAAs) or anti-TAA autoantibodies and their diagnostic values in ovarian cancer (OC).
METHODS
A systematic literature search was conducted in two databases. Data were independently extracted and reviewed by two junior investigators and the disagreement was further resolved by consulting one of the senior investigators.
RESULTS
Sixty publications reporting 113 different TAAs or anti-TAA autoantibodies were included. The majority of the studies were conducted in western countries. CA125, p53 and HE4 were the most frequently tested TAAs in OC. Meta-analysis showed that there was a significant association between serum anti-p53 autoantibody and increased risk of OC.
CONCLUSION
Serum TAAs or anti-TAA autoantibodies are promising diagnostic biomarkers in the detection of OC. A customized mini-array of multiple TAAs may enhance the detection of anti-TAA autoantibodies in OC. Additional studies with sufficient number of OC patients and carefully selected controls are needed to further verify the results.
目的
本系统综述旨在概述和总结已知的肿瘤相关抗原（TAA）或抗 TAA 自身抗体及其在卵巢癌（OC）中的诊断价值。
方法
在两个数据库中进行了系统的文献检索。数据由两名初级研究员独立提取和审查，分歧由一名高级研究员进一步解决。
结果
纳入了 60 篇报道 113 种不同 TAA 或抗 TAA 自身抗体的出版物。大多数研究在西方国家进行。CA125、p53 和 HE4 是 OC 中最常检测的 TAA。荟萃分析表明，血清抗 p53 自身抗体与 OC 风险增加之间存在显著关联。
结论
血清 TAA 或抗 TAA 自身抗体是 OC 检测有前途的诊断生物标志物。多个 TAA 的定制 mini-array 可能会增强 OC 中抗 TAA 自身抗体的检测。需要更多的 OC 患者和精心选择的对照进行额外的研究，以进一步验证结果。
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