• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

认知行为表型的发育轨迹:引言

Developmental trajectories in cognitive-behavioral phenotypes: Introduction.

作者信息

Fisch Gene S

出版信息

Am J Med Genet C Semin Med Genet. 2015 Jun;169(2):131-4. doi: 10.1002/ajmg.c.31441. Epub 2015 May 10.

DOI:10.1002/ajmg.c.31441
PMID:25959524
Abstract

Developmental trajectories in behavioral phenotypes are important areas for systematic research and have been for more than 30 years. They interweave several important strands related to human growth: that of individuals born with some form of intellectual impairment or disability (ID); second, the genetics associated with intellectual ability and disability; and third, at the behavioral level, the dynamic expression and variability of specific abnormalities as individuals age. ID, and the genetic disorders that produce ID, were often not well-received by earlier societies. While the inheritance of behavior and intellectual ability has probably been observed throughout human history, the systematic investigation of the inheritance of intellectual ability probably begins with Sir Francis Galton, in his treatise Hereditary Genius in 1869. The dynamic features of ID have its roots in late 19th century developmental psychology and early 20th century pediatrics. Alfred Binet, along with his colleague Theodore Simon, created the first methods of formal intelligence testing of children for the French school system. Scores based on the items administered would then be used to distinguish children who were prepared for enrollment in a standard educational program from those who were not. The confluence of these research topics brings us to the subject of our Special Issue.

摘要

行为表型的发展轨迹是系统研究的重要领域,这一研究已经开展了30多年。它们交织了与人类成长相关的几个重要方面:一是天生患有某种形式智力障碍或残疾(ID)的个体;二是与智力能力和残疾相关的遗传学;三是在行为层面,随着个体年龄增长特定异常的动态表达和变异性。ID以及导致ID的遗传疾病,在早期社会往往不被人们所接受。虽然行为和智力能力的遗传现象可能在整个人类历史中都被观察到,但对智力能力遗传的系统研究可能始于弗朗西斯·高尔顿爵士,他在1869年发表了论文《遗传的天才》。ID的动态特征源于19世纪后期的发展心理学和20世纪早期的儿科学。阿尔弗雷德·比奈和他的同事西奥多·西蒙为法国学校系统创建了第一种正式的儿童智力测试方法。基于所施测项目的分数随后将用于区分准备进入标准教育项目的儿童和未准备好的儿童。这些研究主题的融合将我们带到了本期特刊的主题。

相似文献

1
Developmental trajectories in cognitive-behavioral phenotypes: Introduction.认知行为表型的发育轨迹:引言
Am J Med Genet C Semin Med Genet. 2015 Jun;169(2):131-4. doi: 10.1002/ajmg.c.31441. Epub 2015 May 10.
2
Confirmation of chromosomal microarray as a first-tier clinical diagnostic test for individuals with developmental delay, intellectual disability, autism spectrum disorders and dysmorphic features.证实染色体微阵列分析可作为发育迟缓、智力障碍、自闭症谱系障碍和发育异常特征的个体的一线临床诊断测试。
Eur J Paediatr Neurol. 2013 Nov;17(6):589-99. doi: 10.1016/j.ejpn.2013.04.010. Epub 2013 May 24.
3
Advances in understanding behavioral phenotypes in neurogenetic syndromes.神经遗传综合征中行为表型的研究进展。
Am J Med Genet C Semin Med Genet. 2010 Nov 15;154C(4):389-99. doi: 10.1002/ajmg.c.30276.
4
Glutamate synapses in human cognitive disorders.谷氨酸能突触在人类认知障碍中的作用。
Annu Rev Neurosci. 2015 Jul 8;38:127-49. doi: 10.1146/annurev-neuro-071714-033821. Epub 2015 Apr 9.
5
Leo Kanner and autism: a 75-year perspective.莱奥·坎纳与自闭症:75 年的视角。
Int Rev Psychiatry. 2018 Feb;30(1):3-17. doi: 10.1080/09540261.2018.1455646. Epub 2018 Apr 18.
6
Making headway with genetic diagnostics of intellectual disabilities.智力障碍的基因诊断取得进展。
Clin Genet. 2014 Feb;85(2):101-10. doi: 10.1111/cge.12244. Epub 2013 Aug 26.
7
Intelligence is only one human attribute: an introduction to the festschrift in honour of Trevor Parmenter, What is intelligence? What is intellectual disability?智力只是人类的一种属性:纪念特雷弗·帕门特的论文集引言,什么是智力?什么是智力残疾?
J Intellect Dev Disabil. 2011 Dec;36(4):219-22. doi: 10.3109/13668250.2011.626159.
8
Behavioral phenotypes of genetic syndromes: a reference guide for psychiatrists.遗传综合征的行为表型:精神科医生参考指南
J Am Acad Child Adolesc Psychiatry. 2001 Jul;40(7):749-61. doi: 10.1097/00004583-200107000-00009.
9
Developmental trajectories in syndromes with intellectual disability, with a focus on Wolf-Hirschhorn and its cognitive-behavioral profile.智力障碍综合征的发展轨迹,重点关注 Wolf-Hirschhorn 综合征及其认知行为特征。
Am J Intellect Dev Disabil. 2012 Mar;117(2):167-79. doi: 10.1352/1944-7558-117.2.167.
10
Dysfunction of SHANK2 and CHRNA7 in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci.SHANK2 和 CHRNA7 功能障碍导致的智力障碍和语言障碍患者支持两个基因座的遗传上位效应。
Clin Genet. 2013 Dec;84(6):560-5. doi: 10.1111/cge.12105. Epub 2013 Feb 21.

引用本文的文献

1
Predictors of Developmental Outcome in 4- to 6-Year-Olds With Developmental Disability.4至6岁发育障碍儿童发育结局的预测因素
Psychiatry Investig. 2022 Jul;19(7):519-526. doi: 10.30773/pi.2021.0385. Epub 2022 Jul 21.