Fisch Gene S
Am J Med Genet C Semin Med Genet. 2015 Jun;169(2):131-4. doi: 10.1002/ajmg.c.31441. Epub 2015 May 10.
Developmental trajectories in behavioral phenotypes are important areas for systematic research and have been for more than 30 years. They interweave several important strands related to human growth: that of individuals born with some form of intellectual impairment or disability (ID); second, the genetics associated with intellectual ability and disability; and third, at the behavioral level, the dynamic expression and variability of specific abnormalities as individuals age. ID, and the genetic disorders that produce ID, were often not well-received by earlier societies. While the inheritance of behavior and intellectual ability has probably been observed throughout human history, the systematic investigation of the inheritance of intellectual ability probably begins with Sir Francis Galton, in his treatise Hereditary Genius in 1869. The dynamic features of ID have its roots in late 19th century developmental psychology and early 20th century pediatrics. Alfred Binet, along with his colleague Theodore Simon, created the first methods of formal intelligence testing of children for the French school system. Scores based on the items administered would then be used to distinguish children who were prepared for enrollment in a standard educational program from those who were not. The confluence of these research topics brings us to the subject of our Special Issue.
行为表型的发展轨迹是系统研究的重要领域,这一研究已经开展了30多年。它们交织了与人类成长相关的几个重要方面:一是天生患有某种形式智力障碍或残疾(ID)的个体;二是与智力能力和残疾相关的遗传学;三是在行为层面,随着个体年龄增长特定异常的动态表达和变异性。ID以及导致ID的遗传疾病,在早期社会往往不被人们所接受。虽然行为和智力能力的遗传现象可能在整个人类历史中都被观察到,但对智力能力遗传的系统研究可能始于弗朗西斯·高尔顿爵士,他在1869年发表了论文《遗传的天才》。ID的动态特征源于19世纪后期的发展心理学和20世纪早期的儿科学。阿尔弗雷德·比奈和他的同事西奥多·西蒙为法国学校系统创建了第一种正式的儿童智力测试方法。基于所施测项目的分数随后将用于区分准备进入标准教育项目的儿童和未准备好的儿童。这些研究主题的融合将我们带到了本期特刊的主题。