State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (China).
Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7657-61. doi: 10.1002/anie.201502405. Epub 2015 May 8.
A novel and efficient palladium-catalyzed hydroaminocarbonylation of alkenes with aminals has been developed under mild reaction conditions, and allows the synthesis of a wide range of N-alkyl linear amides in good yields with high regioselectivity. On the basis of this method, a cooperative catalytic system operating by the synergistic combination of palladium, paraformaldehyde, and acid was established for promoting the hydroaminocarbonylation of alkenes with both aromatic and aliphatic amines, which do not react well under conventional palladium-catalyzed hydroaminocarbonylation.
开发了一种新颖、高效的钯催化烯烃与亚胺的氢氨甲酰化反应，在温和的反应条件下，能够以高区域选择性合成广泛的 N-烷基直链酰胺，产率良好。在此方法的基础上，建立了一种协同催化体系，通过钯、多聚甲醛和酸的协同组合来促进烯烃与芳胺和脂肪胺的氢氨甲酰化反应，这在传统的钯催化氢氨甲酰化反应中不易进行。
