Tapp Maeling, Sullivan Rick, Dennis Patrick, Naik Rajesh R, Milam Valeria T
School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.
Materials & Manufacturing Directorate, Soft Matter Materials Branch, Air Force Research Laboratory, Wright Patterson AFB, OH 45433, USA.
J Mater Res. 2015 Mar 14;30(5):666-676. doi: 10.1557/jmr.2014.409.
The effect of adding nucleic acids to gold seeds during the growth stage of either nanospheres or nanorods was investigated using UV-Vis spectroscopy to reveal any oligonucleotide base or structure-specific effects on nanoparticle growth kinetics or plasmonic signatures. Spectral data indicate that the presence of DNA duplexes during seed ageing drastically accelerated nanosphere growth while the addition of single-stranded polyadenine at any point during seed ageing induces nanosphere aggregation. For seeds added to a gold nanorod growth solution, single-stranded polythymine induces a modest blue-shift in the longitudinal peak wavelength. Moreover, a particular sequence comprised of 50% thymine bases was found to induce a faster, more dramatic blue-shift in the longitudinal peak wavelength compared to any of the homopolymer incubation cases. Monomeric forms of the nucleic acids, however, do not yield discernable spectral differences in any of the gold suspensions studied.
在纳米球或纳米棒的生长阶段向金种子中添加核酸的效果，通过紫外可见光谱进行了研究，以揭示任何寡核苷酸碱基或结构对纳米颗粒生长动力学或等离子体特征的特异性影响。光谱数据表明，在种子老化过程中DNA双链的存在极大地加速了纳米球的生长，而在种子老化的任何阶段添加单链聚腺嘌呤都会诱导纳米球聚集。对于添加到金纳米棒生长溶液中的种子，单链聚胸腺嘧啶会使纵向峰波长发生适度的蓝移。此外，发现由50%胸腺嘧啶碱基组成的特定序列，与任何均聚物孵育情况相比，会使纵向峰波长发生更快、更显著的蓝移。然而，在所研究的任何金悬浮液中，核酸的单体形式都不会产生可辨别的光谱差异。
