来自马达加斯加干燥森林的复羽叶南洋参中的生物活性齐墩果烷糖苷。
Bioactive oleanane glycosides from Polyscias duplicata from the Madagascar dry forest.
作者信息
Eaton Alexander L, Brodie Peggy J, Callmander Martin W, Rakotondrajaona Roland, Rakotobe Etienne, Rasamison Vincent E, Kingston David G I
出版信息
Nat Prod Commun. 2015 Apr;10(4):567-70.
As part of the International Cooperative Biodiversity Group (ICBG) program, in a search for antiproliferative compounds, an ethanol extract of Polyscias duplicata was investigated due to its antiproliferative activity against the A2780 human ovarian cell cancer line (IC50 6 µg/mL). Seven known oleanane glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (1, IC50 8 µM), 3β-[(α-L-arabinopyranosyl)oxy]-16α,23-dihydroxyolean-12-en-18-oic acid (2, IC50 13 µM), 3β-[(O-β-D-glucopyranosyl-(t-->3)-α-L-arabinopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (3, IC50 7 µM), 3β-[(O-α-L-rhamnopyranosyl-(1-2)-α-L-arabinopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (4, IC50 2.8 µM), 3β-[(O-β-D-glucopyranosyl-(l-->3)-α-L- arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (5, IC50 10 µM), β-[(O-α-L-rhamnopyranosyl-(-1.2)-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (6, IC50 3.4 µM), and 3β-[(α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (7, IC50 3.4 µM) were isolated, and their structures determined using spectroscopic methods.
作为国际合作生物多样性小组（ICBG）项目的一部分，为寻找抗增殖化合物，对复羽叶南洋参乙醇提取物进行了研究，因其对A2780人卵巢癌细胞系具有抗增殖活性（半数抑制浓度为6μg/mL）。分离出了七种已知的齐墩果烷糖苷，分别为3β-[(α-L-阿拉伯吡喃糖基)氧基]-16α-羟基齐墩果-12-烯-28-酸（1，半数抑制浓度为8μM）、3β-[(α-L-阿拉伯吡喃糖基)氧基]-16α,23-二羟基齐墩果-12-烯-18-酸（2，半数抑制浓度为13μM）、3β-[(O-β-D-吡喃葡萄糖基-(t→3)-α-L-阿拉伯吡喃糖基)氧基]-16α-羟基齐墩果-12-烯-28-酸（3，半数抑制浓度为7μM）、3β-[(O-α-L-鼠李吡喃糖基-(1→2)-α-L-阿拉伯吡喃糖基)氧基]-16α-羟基齐墩果-12-烯-28-酸（4，半数抑制浓度为2.8μM）、3β-[(O-β-D-吡喃葡萄糖基-(l→3)-α-L-阿拉伯吡喃糖基)氧基]-23-羟基齐墩果-12-烯-28-酸（5，半数抑制浓度为10μM）、β-[(O-α-L-鼠李吡喃糖基-(-1.2)-α-L-阿拉伯吡喃糖基)氧基]-23-羟基齐墩果-12-烯-28-酸（6，半数抑制浓度为3.4μM）和3β-[(α-L-阿拉伯吡喃糖基)氧基]-23-羟基齐墩果-12-烯-28-酸（7，半数抑制浓度为3.4μM），并采用光谱方法确定了它们的结构。
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