Liu Xin, Cui Yanxing, Yu Qiang, Yu Biao
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China.
Phytochemistry. 2005 Jul;66(14):1671-9. doi: 10.1016/j.phytochem.2005.05.011.
Seven triterpenoids, i.e., 3beta-[(alpha-L-arabinopyranosyl)oxy]-19beta-hydroxyurs-12,20(30)-dien-28-oic acid (1), 3beta-[(alpha-L-arabinopyranosyl)oxy]-urs-11,13(18)-dien-28-oic acid beta-D-glucopyranosyl ester (2), 2alpha,3alpha,23-trihydroxyurs-12-en-24,28-dioic acid 28-beta-D-glucopyranosyl ester (3), 3beta-[(alpha-L-arabinopyranosyl)oxy]-urs-12,19(20)-dien-28-oic acid (4), 3beta-[(alpha-L-arabinopyranosyl)oxy]-urs-12,19(29)-dien-28-oic acid (5), 3beta-[(alpha-L-arabinopyranosyl)oxy]-19alpha-hydroxyolean-12-en-28-oic acid (6), 2alpha,3beta-dihydroxy-28-norurs-12,17,19(20),21-tetraen-23-oic cid (7), together with three known ones (8-10), were isolated from the roots of Sanguisorba officinalis. Their structures were determined by spectroscopic and chemical methods. Compounds 7 and 10 showed marginal inhibition activity against the growth of tumor cell lines.
从地榆的根部分离得到7种三萜类化合物，即3β-[(α-L-阿拉伯吡喃糖基)氧基]-19β-羟基乌苏-12,20(30)-二烯-28-酸（1）、3β-[(α-L-阿拉伯吡喃糖基)氧基]-乌苏-11,13(18)-二烯-28-酸β-D-吡喃葡萄糖基酯（2）、2α,3α,23-三羟基乌苏-12-烯-24,28-二酸28-β-D-吡喃葡萄糖基酯（3）、3β-[(α-L-阿拉伯吡喃糖基)氧基]-乌苏-12,19(20)-二烯-28-酸（4）、3β-[(α-L-阿拉伯吡喃糖基)氧基]-乌苏-12,19(29)-二烯-28-酸（5）、3β-[(α-L-阿拉伯吡喃糖基)氧基]-19α-羟基齐墩果-12-烯-28-酸（6）、2α,3β-二羟基-28-降乌苏-12,17,19(20),21-四烯-23-酸（7），以及3种已知化合物（8 - 10）。通过光谱和化学方法确定了它们的结构。化合物7和10对肿瘤细胞系的生长表现出微弱的抑制活性。
