辅助化疗后乳腺癌患者发生急性髓系白血病（AML）：病例报告及文献复习
Appearance of Acute Myelogenous Leukemia (AML) in a Patient with Breast Cancer after Adjuvant Chemotherapy: Case Report and Review of the Literature.
作者信息
Payandeh Mehrdad, Khodarahmi Reza, Sadeghi Masoud, Sadeghi Edris
机构信息
Dept. of Hematology, Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Iran J Cancer Prev. 2015 Mar-Apr;8(2):125-8.
Abstract
Acute Myelogenous Leukemia (AML) is an aggressive hematologic malignancy that cause by abnormal proliferation and accumulation of hematopoietic progenitor cells. A 37-year-old woman referred to oncologic clinic with a self-detected mass and pain in her left breast. The stage of tumor was ΙΙΙA. She was treated with the combination of anthracycline and cyclophosphamide for four courses, followed by four courses of paclitaxel with trastuzumab for one year. After 18 months of the first treatment for breast cancer, her bone marrow biopsy was compatible with AML-M2. Here, we are reporting a young woman case with breast cancer that developed AML malignancy during short interval of therapy.
摘要
急性髓系白血病（AML）是一种侵袭性血液系统恶性肿瘤，由造血祖细胞异常增殖和积累引起。一名37岁女性因自我发现左乳房肿块和疼痛转诊至肿瘤诊所。肿瘤分期为ⅢA期。她接受了四个疗程的蒽环类药物和环磷酰胺联合治疗，随后接受了四个疗程的紫杉醇联合曲妥珠单抗治疗，为期一年。在首次治疗乳腺癌18个月后，她的骨髓活检结果与AML-M2相符。在此，我们报告一例年轻女性乳腺癌患者，在短时间治疗期间发生了AML恶性肿瘤。
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