诱导性甲状腺功能减退和他汀类药物治疗背景下的横纹肌溶解症：一例报告。
Rhabdomyolysis in the setting of induced hypothyroidism and statin therapy: a case report.
作者信息
Jbara Yaser, Bricker Dean
机构信息
Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA.
出版信息
Eur Thyroid J. 2015 Mar;4(1):62-4. doi: 10.1159/000371548. Epub 2015 Feb 18.
Abstract
Mild elevation of creatine kinase (CK) is common in untreated hypothyroidism, but severe myositis and overt rhabdomyolysis are rare. Similarly, muscle pain and CK elevation are potential side effects of statin therapy, yet rhabdomyolysis is likewise rare in the absence of medication interactions adversely affecting statin metabolism. The coexistence of statin therapy and hypothyroid states may synergistically increase the risk of myopathy. We describe a case of rhabdomyolysis attributable to induced hypothyroidism in a patient on chronic statin medication who was anticipating adjuvant radioiodine ((131)I) therapy for a thyroid carcinoma.
摘要
肌酸激酶（CK）轻度升高在未经治疗的甲状腺功能减退症中很常见，但严重的肌炎和明显的横纹肌溶解很少见。同样，肌肉疼痛和CK升高是他汀类药物治疗的潜在副作用，但在没有药物相互作用对他汀类药物代谢产生不利影响的情况下，横纹肌溶解同样罕见。他汀类药物治疗与甲状腺功能减退状态并存可能会协同增加患肌病的风险。我们描述了一例横纹肌溶解病例，该病例发生在一名长期服用他汀类药物的患者身上，该患者因甲状腺癌正准备接受辅助放射性碘（（131）I）治疗，横纹肌溶解由诱导性甲状腺功能减退引起。
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