Chaudhary Neera, Duggal Ashish Kumar, Makhija Prashant, Puri Vinod, Khwaja Geeta Anjum
Department of Neurology, Govind Ballabh Pant Hospital, New Delhi, India.
Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):331-4. doi: 10.4103/0972-2327.157251.
Muscle involvement is a common manifestation of both clinical and subclinical hypothyroidism, with serum creatine kinase (CK) elevation being probably the most common manifestation, and is seen in up to 90% of patients, but is usually mild (less than 10 times the upper limit of normal). Rhabdomyolysis is a distinctively uncommon presentation of hypothyroidism described usually in the setting of precipitating events such as strenuous exercise, alcohol, or statin use. Rarely rhabdomyolysis and myoedema seen in hypothyroidism can be complicated by the development of anterior compartment syndrome leading to neurovascular compression. We describe a case of a patient with hypothyroidism who developed acute onset bilateral foot drop on initiation of statins. This case highlights the need for cautious use of statins in patients at risk for rhabdomyolysis.
肌肉受累是临床和亚临床甲状腺功能减退症的常见表现，血清肌酸激酶（CK）升高可能是最常见的表现，在高达90%的患者中可见，但通常较轻（低于正常上限的10倍）。横纹肌溶解症是甲状腺功能减退症一种极为罕见的表现，通常在剧烈运动、饮酒或使用他汀类药物等诱发因素的情况下出现。甲状腺功能减退症中罕见的横纹肌溶解症和肌水肿可能因前间隔综合征的发展而复杂化，导致神经血管受压。我们描述了一例甲状腺功能减退症患者在开始使用他汀类药物后急性出现双侧足下垂的病例。该病例强调了在有横纹肌溶解症风险的患者中谨慎使用他汀类药物的必要性。
