Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland; Department of Pediatrics, Kymenlaakso Central Hospital, Kotka, Finland.
Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
J Pediatr. 2015 Jul;167(1):125-30. doi: 10.1016/j.jpeds.2015.04.015. Epub 2015 May 9.
To determine whether maternal preeclampsia influences insulin sensitivity (IS) or its biochemical markers in offspring.
Sixty children born from a preeclamptic pregnancy (PRE) and 60 matched control subjects born from a normotensive pregnancy (non-PRE) were studied at age 12 years. IS was estimated using the Quantitative Insulin Sensitivity Check Index (QUICKI), and serum concentrations of adiponectin, leptin, insulin-like growth factor (IGF)-1, IGF-2, IGF-binding protein-1 (IGFBP-1), sex hormone-binding globulin, lipids, and casual blood pressure (BP) were measured.
The mean values of QUICKI, serum adiponectin, leptin, IGF-1, IGF-2, IGFBP-1, and sex hormone-binding globulin did not differ between the PRE group and non-PRE group (P > .05 for all). The PRE subjects with the lowest IS (the lowest QUICKI tertile; n = 20) had significantly higher mean serum leptin (P = .007), triglyceride (P = .008), and IGF-1 (P = .005) levels and systolic BP (P = .019), and lower serum IGFBP-1 level (P = .007) compared with PRE subjects with higher QUICKI values (n = 40). Similarly, in logistic regression analysis, higher serum leptin (OR, 1.2; P = .009), triglyceride (OR, 1.2; P = .040), and IGF-1 (OR, 1.1; P = .031) levels and systolic BP (OR, 5.8; P = .024) were associated with low QUICKI in the PRE group.
Maternal preeclampsia did not produce decreased IS in offspring by age of 12 years. However, the offspring with the lowest IS had higher mean serum triglyceride level and systolic BP, suggesting that components of the metabolic syndrome may cluster in this subgroup.
确定母亲子痫前期是否会影响后代的胰岛素敏感性（IS）或其生化标志物。
这项研究共纳入 60 名来自子痫前期妊娠的儿童（PRE 组）和 60 名来自正常血压妊娠的儿童（非 PRE 组）。在 12 岁时，使用定量胰岛素敏感性检查指数（QUICKI）评估 IS，测量血清脂联素、瘦素、胰岛素样生长因子（IGF）-1、IGF-2、IGF 结合蛋白-1（IGFBP-1）、性激素结合球蛋白、血脂和偶然血压（BP）。
PRE 组和非 PRE 组的 QUICKI、血清脂联素、瘦素、IGF-1、IGF-2、IGFBP-1 和性激素结合球蛋白的平均值无差异（所有 P 值均＞.05）。IS 最低的 PRE 组受试者（最低 QUICKI 三分位组；n = 20）的血清瘦素（P =.007）、甘油三酯（P =.008）和 IGF-1（P =.005）水平以及收缩压（P =.019）更高，IGFBP-1 水平更低（P =.007），与 QUICKI 值较高的 PRE 组受试者（n = 40）相比。同样，在逻辑回归分析中，较高的血清瘦素（OR，1.2；P =.009）、甘油三酯（OR，1.2；P =.040）、IGF-1（OR，1.1；P =.031）和收缩压（OR，5.8；P =.024）与 PRE 组的低 QUICKI 相关。
到 12 岁时，母亲子痫前期并未导致后代的 IS 降低。然而，IS 最低的后代的血清甘油三酯水平和收缩压较高，表明代谢综合征的成分可能在这一分组中聚集。
