Yousefi Mehdi, Movassaghpour Ali Akbar, Shamsasenjan Karim, Ghalamfarsa Ghasem, Sadreddini Sanam, Jadidi-Niaragh Farhad, Hojjat-Farsangi Mohammad
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Future Oncol. 2015;11(10):1567-82. doi: 10.2217/fon.14.298.
While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases. B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western world and is characterized with monoclonal expansion of B lymphocytes. There is evidence which implies that the progression of CLL is associated with expansion of Treg and downregulation of Th17 cells. In this review, we will discuss about immunobiology of Treg and Th17 cells and their role in immunopathogenesis of CLL as well as their reciprocal changes during disease progression.
虽然调节性T细胞维持自身耐受性并抑制抗肿瘤反应，但辅助性T（Th）17细胞可能增强炎症和抗肿瘤反应。在许多免疫病理状况（如自身免疫性疾病和癌症疾病）中，这两个重要的T细胞亚群之间的平衡已被打破。B细胞慢性淋巴细胞白血病（CLL）是西方世界最常见的白血病形式，其特征是B淋巴细胞的单克隆扩增。有证据表明，CLL的进展与调节性T细胞的扩增和Th17细胞的下调有关。在这篇综述中，我们将讨论调节性T细胞和Th17细胞的免疫生物学及其在CLL免疫发病机制中的作用，以及它们在疾病进展过程中的相互变化。
