González R, Carbajal D, Wyczolkowska J
National Center of Scientific Research, Havana, Cuba.
Agents Actions. 1989 Nov;28(3-4):168-72. doi: 10.1007/BF01967397.
The effect of disodium 4-chloro-2,2-iminodibenzoate (CCA) on IgE antibody response was examined in C3H/A and (BALB/c x C57BL/6J) F1 hybrid mice immunized with low doses of ovalbumin (OA) adsorbed on aluminium hydroxide gel. CCA administered orally at the doses of 5 and 50 mg/kg/day reduced IgE antibody production in these mice as determined by PCA test. High doses of CCA (100 mg/kg/day) given from day 7 before immunization of C57BL mice and during 1 week after immunization of mice with OA and Bordetella Pertussis Vaccine reduced the mortality of these mice subjected to anaphylactic shock on day 7 of immunization. CCA treatment was ineffective in anaphylactic shock of C57BL mice immunized with very high dose of OA, known to elicit little or no IgE antibody production but high IgG antibody response. The treatment of OA-immunized Guinea pigs with one oral dose of CCA (100 mg/kg) did not reduce mortality in protracted anaphylactic shock. Our results demonstrate that CCA inhibits IgE production as well as IgE mediated hypersensitivity reactions in mice.
在以吸附于氢氧化铝凝胶上的低剂量卵清蛋白（OA）免疫的C3H/A和（BALB/c×C57BL/6J）F1杂种小鼠中，检测了4-氯-2,2-亚氨基二苯甲酸二钠（CCA）对IgE抗体反应的影响。通过PCA试验测定，以5和50mg/kg/天的剂量口服给予CCA可降低这些小鼠中IgE抗体的产生。在C57BL小鼠免疫前7天至用OA和百日咳疫苗免疫小鼠后的1周内，给予高剂量的CCA（100mg/kg/天）可降低这些在免疫第7天遭受过敏性休克的小鼠的死亡率。CCA处理对用非常高剂量OA免疫的C57BL小鼠的过敏性休克无效，已知该高剂量OA几乎不引发或不引发IgE抗体产生，但会引发高IgG抗体反应。用一剂口服CCA（100mg/kg）处理OA免疫的豚鼠，在持续性过敏性休克中并未降低死亡率。我们的结果表明，CCA可抑制小鼠中的IgE产生以及IgE介导的超敏反应。
