Gupta Malkeet, Gertz Michael, Schriger David L
Department of Emergency Medicine, UCLA School of Medicine, Los Angeles, CA.
Antelope Valley Emergency Department, Lancaster, CA.
Ann Emerg Med. 2016 Jan;67(1):71-75.e3. doi: 10.1016/j.annemergmed.2015.03.033. Epub 2015 May 9.
All articles that demonstrate a mortality benefit from liberal pan-computed tomography (CT) use in patients with blunt trauma have relied on Injury Severity Score (ISS) to control for morbidity. This mortality benefit may be artifact, the result of an increased use of a sensitive diagnostic modality rather than a true benefit. We quantify the magnitude of ISS inflation in patients with blunt trauma who are undergoing routine pan-CT compared with patients who receive more selective scanning.
This study re-analyzes data collected from a previous study of pan-CT use in patients with blunt trauma in which surveyed emergency physicians prospectively indicated which portion of a pan-CT they wished to obtain. The trauma surgeons who jointly managed all patients in this study ultimately decided which CTs to obtain. We recalculated the ISS excluding injuries found on the undesired CT scans that did not lead to a predefined set of critical actions and compared original and recalculated ISS.
There were 701 study subjects who received a total of 2,615 scans. Of these, there were 992 undesired scans. Ninety-nine of the obtained undesired scans, performed in 92 patients, had noncritical abnormalities. The original ISS for these 92 patients was 10 (IQR 5, 18); the recalculated ISS was 5 (interquartile range 1, 10), a 50% decrease.
Although the median ISS for our study was lower than that of previous studies claiming a mortality benefit, ISS inflation appears to be a real phenomenon and may confound studies that use ISS to control for morbidity.
所有表明在钝性创伤患者中广泛使用全计算机断层扫描(CT)可带来死亡率益处的文章,都依赖损伤严重度评分(ISS)来控制发病率。这种死亡率益处可能是假象,是使用了更敏感的诊断方式导致的结果,而非真正的益处。我们对接受常规全CT扫描的钝性创伤患者与接受更具选择性扫描的患者相比,ISS升高的幅度进行了量化。
本研究重新分析了之前一项关于钝性创伤患者使用全CT的研究中收集的数据,在该研究中,接受调查的急诊医生前瞻性地指出他们希望获取全CT的哪一部分。共同管理本研究中所有患者的创伤外科医生最终决定获取哪些CT扫描。我们重新计算了ISS,排除了在未进行的CT扫描中发现的、未导致一组预定义关键操作的损伤,并比较了原始ISS和重新计算后的ISS。
共有701名研究对象,总共进行了2615次扫描。其中,有992次是未进行的扫描。在92名患者中进行的99次未进行的扫描发现了非关键异常。这92名患者的原始ISS为10(四分位间距5,18);重新计算后的ISS为5(四分位间距1,10),降低了50%。
尽管我们研究的ISS中位数低于之前声称有死亡率益处的研究,但ISS升高似乎是一个真实现象,可能会混淆使用ISS来控制发病率的研究。