Lai Lillian M, McCarville M Beth, Kirby Patricia, Kao Simon C S, Moritani Toshio, Clark Eve, Ishigami Kousei, Bahrami Armita, Sato Yutaka
Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
Department of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pediatr Radiol. 2015 Nov;45(12):1738-52. doi: 10.1007/s00247-015-3360-6. Epub 2015 May 12.
Inflammatory pseudotumor is a generic term used to designate a heterogeneous group of inflammatory mass-forming lesions histologically characterized by myofibroblastic proliferation with chronic inflammatory infiltrate. Inflammatory pseudotumor is multifactorial in etiology and generally benign, but it is often mistaken for malignancy given its aggressive appearance. It can occur throughout the body and is seen in all age groups. Inflammatory pseudotumor has been described in the literature by many organ-specific names, resulting in confusion. Recently within this generic category of inflammatory pseudotumor, inflammatory myofibroblastic tumor has emerged as a distinct entity and is now recognized as a fibroblastic/myofibroblastic neoplasm with intermediate biological potential and occurring mostly in children. We present interesting pediatric cases of inflammatory myofibroblastic tumors given this entity's tendency to occur in children. Familiarity and knowledge of the imaging features of inflammatory pseudotumor can help in making an accurate diagnosis, thereby avoiding unnecessary radical surgery.
炎性假瘤是一个通用术语，用于指代一组组织学上以肌成纤维细胞增生伴慢性炎性浸润为特征的异质性炎性肿块形成性病变。炎性假瘤病因多因素，通常为良性，但鉴于其侵袭性表现常被误诊为恶性肿瘤。它可发生于全身，可见于所有年龄组。炎性假瘤在文献中有许多器官特异性名称，导致混淆。最近，在炎性假瘤这一通用类别中，炎性肌成纤维细胞瘤已成为一种独特的实体，现在被认为是一种具有中等生物学潜能且主要发生于儿童的成纤维细胞/肌成纤维细胞肿瘤。鉴于该实体倾向于发生在儿童中，我们展示了有趣的儿童炎性肌成纤维细胞瘤病例。熟悉炎性假瘤的影像学特征有助于做出准确诊断，从而避免不必要的根治性手术。
