来自星毛鹅掌柴的降羽扇烷三萜和愈创木烷倍半萜。

Nor-lupane triterpenoid and guaiane sesquiterpenoids from Schefflera venulosa.

作者信息

Peng Li-Yan, Xu Gang, He Juan, Wu Xing-De, Dong Liao-Bin, Gao Xiu, Cheng Xiao, Su Jia, Li Yan, Dong Wen-Ming, Zhao Qin-Shi

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; Faculty of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, PR China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

出版信息

Fitoterapia. 2015 Jun;103:294-8. doi: 10.1016/j.fitote.2015.05.005. Epub 2015 May 9.

DOI:10.1016/j.fitote.2015.05.005

PMID:25964186

Abstract

A novel nor-lupane triterpenoid, 3-oxo-29α-hydroxy-17β,20-epoxy-28-norlupane (1), and two new guaiane sesquiterpenoids, schvenols A-B (2-3), has been isolated from leaves of Schefflera venulosa. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. And the structure of 1 was further confirmed by the X-ray diffraction analysis. None of the compounds showed inhibitory effects on NO release in LPS-stimulated RAW 264.7 macrophage cell line.

摘要

从星毛鹅掌柴的叶子中分离出了一种新型降羽扇烷三萜3-氧代-29α-羟基-17β,20-环氧-28-降羽扇烷（1）以及两种新的愈创木烷倍半萜schvenols A - B（2 - 3）。通过包括一维和二维核磁共振技术在内的光谱方法阐明了这些新化合物的结构。并且通过X射线衍射分析进一步确证了化合物1的结构。这些化合物在脂多糖刺激的RAW 264.7巨噬细胞系中均未表现出对一氧化氮释放的抑制作用。