肾移植后白细胞介素-10和转化生长因子-β水平与短期移植肾功能的关系
Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation.
作者信息
Colak H, Ersan S, Tanrisev M, Kurtulmus Y, Degirmenci P, Comert S, Tugmen C, Ceylan C
机构信息
Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey.
Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey.
出版信息
Transplant Proc. 2015 Jun;47(5):1360-3. doi: 10.1016/j.transproceed.2015.02.013. Epub 2015 May 8.
INTRODUCTION
We evaluated the relationship of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) levels with graft function in kidney transplantation patients receiving tacrolimus-based immunosuppression during the early post-transplantation period.
MATERIAL AND METHODS
There were 112 patients who underwent kidney transplantation from live donors between May 2011 and May 2013. Eight patients had at least 1 of the exclusion criteria, and the remaining 104 patients were included in the study. The recipients underwent evaluation for biochemical markers, complete blood count, and creatinine and cytokine (IL-10, TGF-β) levels during the pretransplantation and post-transplantation 6 months.
RESULTS
The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-β levels in both the pretransplantation and early post-transplantation period.
CONCLUSION
Low serum TGF-β and high IL-10 levels at post-transplantation month 6 might have a positive effect on graft survival in living donor kidney recipients on tacrolimus-based immunosuppressive treatment.
引言
我们评估了在肾移植术后早期接受基于他克莫司的免疫抑制治疗的患者中，白细胞介素-10（IL-10）和转化生长因子-β（TGF-β）水平与移植肾功能的关系。
材料与方法
2011年5月至2013年5月期间，有112例接受活体供肾肾移植的患者。8例患者至少有1项排除标准，其余104例患者纳入研究。在移植前和移植后6个月，对受者进行生化指标、全血细胞计数、肌酐和细胞因子（IL-10、TGF-β）水平评估。
结果
在移植前和移植后早期，肌酐水平与IL-10呈负相关，与TGF-β水平呈正相关。
结论
移植后第6个月血清TGF-β水平低和IL-10水平高可能对接受基于他克莫司免疫抑制治疗的活体供肾受者的移植肾存活有积极影响。
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