Valcárcel F, Aguilar A, Sánchez M
Grupo de Parasitología Animal, Centro de Investigación en Sanidad Animal (INIA-CISA), 28130 Valdeolmos, Madrid, Spain.
Vet Parasitol. 2015 Jun 30;211(1-2):71-9. doi: 10.1016/j.vetpar.2015.04.014. Epub 2015 Apr 24.
Targeted selective treatments (TST) are designed to identify those animals that would actually benefit from anthelmintic treatment, thus reducing the amount of drugs used and bringing down economic cost. In this study we assayed three TST programs based on GIN egg output, clinical sign and live weight criteria in a single area where only sub-clinical infections tend to occur and no anthelmintic resistance is reported. The study was carried out from February 2011 to August 2013 on four farms applying different management systems: an Ovine Extensive System, Ovine Semi-extensive Semi-irrigated System focusing on "Rubia del Molar" and Colmenareña" breeds, Ovine Semi-extensive System and Caprine Organic Semi-extensive System. The number of sheep and goats treated in all the TST strategies was lower in comparison with systematic treatments, especially when selected based on clinical signs (100%, in both years), followed by egg output (87.57% and 90.44% in the first and second year respectively) and finally by live weight (37.95% and 96.69%, in the first and second year respectively). FEC was low throughout the study for all animals and groups. Apparently, the TST applied did not influence live body weight. Preliminary results show that all three targeted selective treatments significantly reduced the number of animals treated and the cost of anthelmintic treatment on the farms, maintaining productivity in a low challenge environment. These results also seem to indicate that systematic anthelmintic treatments are unnecessary under these circumstances and traditional anthelmintic regimes should therefore be modified.
靶向选择性治疗（TST）旨在识别那些真正能从驱虫治疗中获益的动物，从而减少药物使用量并降低经济成本。在本研究中，我们在一个仅倾向于发生亚临床感染且未报告有驱虫抗性的单一区域，基于胃肠道线虫虫卵产量、临床症状和体重标准，对三种TST方案进行了测定。该研究于2011年2月至2013年8月在四个采用不同管理系统的农场进行：一个绵羊粗放型系统、一个专注于“鲁维亚·德尔·莫拉尔”和“科尔梅纳雷尼亚”品种的绵羊半粗放半灌溉系统、一个绵羊半粗放系统和一个山羊有机半粗放系统。与系统性治疗相比，所有TST策略中治疗的绵羊和山羊数量都较少，尤其是基于临床症状进行选择时（两年均为100%），其次是虫卵产量（第一年和第二年分别为87.57%和90.44%），最后是体重（第一年和第二年分别为37.95%和96.69%）。在整个研究过程中，所有动物和组的粪便虫卵计数都很低。显然，所应用的TST对体重没有影响。初步结果表明，所有三种靶向选择性治疗都显著减少了农场中接受治疗的动物数量和驱虫治疗成本，在低感染压力环境下维持了生产力。这些结果似乎还表明，在这些情况下系统性驱虫治疗是不必要的，因此应修改传统的驱虫方案。
