使用FAP对II/III期食管鳞状细胞癌患者进行诱导化疗。
Induction Chemotherapy Using FAP for Patients with Stage II/III Squamous Cell Carcinoma of the Esophagus.
作者信息
Tamura Shigeyuki, Takeno Atsushi, Taniguchi Hirokazu, Katsura Yoshiteru, Ohmura Yoshiaki, Kagawa Yoshinori, Sakisaka Hideki, Takeda Yutaka, Kato Takeshi
机构信息
Department of Surgery, Kansai Rosai Hospital, Hyogo, Japan
Department of Surgery, Kansai Rosai Hospital, Hyogo, Japan.
出版信息
Anticancer Res. 2015 May;35(5):2975-82.
BACKGROUND
The aim of this study were to evaluate the feasibility and efficacy of chemotherapy using fluorouracil, adriamycin, and cisplatin (FAP) in patients with clinical stage II/III squamous cell carcinoma of the esophagus (SCCE).
PATIENTS AND METHODS
Forty patients were enrolled in the study. They received 30 mg/m(2) adriamycin and 70 mg/m(2) cisplatin on day 1, and 700 mg/m(2) 5-fluorouracil on days 1-5 every four weeks. Following two courses of chemotherapy, eligible patients underwent esophagectomy.
RESULTS
Twenty-one patients (53%) achieved partial response, and 27 patients underwent surgical resection (resection rate: 68%). Grade 3/4 toxicities developed: 7 patients (18%) with leukopenia, 23 (58%) with neutropenia. The three and five-year survival rates were 55% and 48%. Patients with surgical resection had better prognosis than those without resection, with a three-year survival rate of 68% vs. 25%.
CONCLUSION
FAP is effective and feasible and surgery may provide additional benefit for SCCE patients with FAP.
背景
本研究旨在评估氟尿嘧啶、阿霉素和顺铂（FAP）化疗方案对临床II/III期食管鳞状细胞癌（SCCE）患者的可行性和疗效。
患者与方法
40例患者纳入本研究。他们在第1天接受30mg/m²阿霉素和70mg/m²顺铂治疗，并在第1 - 5天接受700mg/m² 5-氟尿嘧啶治疗，每四周重复一次。两个化疗疗程后，符合条件的患者接受食管切除术。
结果
21例患者（53%）获得部分缓解，27例患者接受了手术切除（切除率：68%）。出现3/4级毒性反应：7例患者（18%）出现白细胞减少，23例（58%）出现中性粒细胞减少。三年和五年生存率分别为55%和48%。接受手术切除的患者预后优于未切除的患者，三年生存率分别为68%和25%。
结论
FAP化疗方案有效且可行，手术可能为接受FAP化疗的SCCE患者带来额外益处。
Zotero 插件