¹⁸F-FDG-PET/CT成像在发热性中性粒细胞减少症和血液系统恶性肿瘤患者中的应用

¹⁸F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies.

作者信息

Camus Vincent, Edet-Sanson Agathe, Bubenheim Michael, Hitzel Anne, Becker Stéphanie, David Marion, Stamatoullas Aspasia, Lenain Pascal, Jardin Fabrice, Contentin Nathalie, Fontoura Marie Laure, Cardinael Nathalie, Vaudaux Sandrine, Dubois Sydney, Tilly Hervé, Vera Pierre, Leprêtre Stéphane

机构信息

Department of Haematology, Centre Henri Becquerel, Rouen, France.

Nuclear Medicine, QuantIF, Centre Henri Becquerel, Rouen, France.

出版信息

Anticancer Res. 2015 May;35(5):2999-3005.

PMID:25964587

Abstract

The aim of the present study was to assess the prevalence of hyper-metabolic infection sites revealed by fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) in patients with febrile neutropenia (FN). Forty-eight consecutive patients with haematological malignancies and persistent FN (temperature ≥ 38°C and neutrophil count <500 cells/μl for more than two days) as a consequence of intensive chemotherapy were prospectively included. Pathological FDG uptakes identified 31 foci of infections located in the lungs (n=15, 48.4 %), colon (n=4, 12.9%), pancreas (n=2, 6.5%), skin (n=3, 9.7%), ear-nose-throat area (n=5, 16.1%), central venous catheter tract (n=1, 3.2%) and gallbladder (n=1, 3.2%). These pathological FDG uptakes were observed in half of the 48 patients (n=24). Among the 38 patients with a clinical diagnosis of infection, 23 showed a pathological FDG uptake, resulting in a FDG-PET/CT sensitivity of 61% (95% CI, 43-76%). Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN.

摘要

本研究的目的是评估氟-18（¹⁸F）氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）联合计算机断层扫描（CT）在发热性中性粒细胞减少症（FN）患者中发现的高代谢感染部位的患病率。前瞻性纳入了48例因强化化疗导致血液系统恶性肿瘤且持续FN（体温≥38°C且中性粒细胞计数<500个细胞/μl超过两天）的连续患者。病理性FDG摄取确定了31个感染病灶，位于肺部（n = 15，48.4%）、结肠（n = 4，12.9%）、胰腺（n = 2，6.5%）、皮肤（n = 3，9.7%）、耳鼻喉区域（n = 5，16.1%）、中心静脉导管通路（n = 1，3.2%）和胆囊（n = 1，3.2%）。在48例患者中有一半（n = 24）观察到这些病理性FDG摄取。在38例临床诊断为感染的患者中，23例显示病理性FDG摄取，FDG-PET/CT的敏感性为61%（95%CI，43 - 76%）。我们的研究证实了FDG-PET/CT诊断持续FN患者感染的能力。