Codding C E, Ramseyer L, Allon M, Pitha J, Rodriguez M
Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City.
Am J Kidney Dis. 1989 Dec;14(6):512-5. doi: 10.1016/s0272-6386(89)80152-0.
Vancomycin was used to treat a patient with Staphylococcus aureus endocarditis. After 3 weeks of therapy, the patient developed a diffuse maculopapular rash, which resolved upon stopping the drug. Rechallenge with vancomycin several days later resulted in reappearance of the rash and rapid onset of acute anuric renal failure. Renal biopsy revealed acute granulomatous interstitial nephritis. This is the first report of biopsy-proven vancomycin-induced acute interstitial nephritis. Renal function should be monitored closely in patients receiving vancomycin therapy.
万古霉素被用于治疗一名患有金黄色葡萄球菌性心内膜炎的患者。经过3周的治疗后，该患者出现了弥漫性斑丘疹，停药后皮疹消退。几天后再次使用万古霉素导致皮疹再次出现，并迅速引发急性无尿性肾衰竭。肾活检显示为急性肉芽肿性间质性肾炎。这是首例经活检证实的万古霉素诱导的急性间质性肾炎报告。接受万古霉素治疗的患者应密切监测肾功能。
