糖基磷脂酰肌醇锚定的MICA等位基因对新型基于NKG2D的疗法的影响。 - Suppr

Suppr

超能文献

The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies.

作者信息

Valés-Gómez Mar

机构信息

Department of Immunology and Oncology, National Centre for Biotechnology (CNB-CSIC) , Madrid , Spain.

出版信息

Front Immunol. 2015 Apr 27;6:193. doi: 10.3389/fimmu.2015.00193. eCollection 2015.

DOI:10.3389/fimmu.2015.00193

PMID:25964786

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4410604/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8507/4410604/02fa796c5c21/fimmu-06-00193-g001.jpg

相似文献

The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies.糖基磷脂酰肌醇锚定的MICA等位基因对新型基于NKG2D的疗法的影响。

Front Immunol. 2015 Apr 27;6:193. doi: 10.3389/fimmu.2015.00193. eCollection 2015.

Glycosyl-Phosphatidyl-Inositol (GPI)-Anchors and Metalloproteases: Their Roles in the Regulation of Exosome Composition and NKG2D-Mediated Immune Recognition.糖基磷脂酰肌醇 (GPI)-锚定蛋白和金属蛋白酶：在调节外泌体组成和 NKG2D 介导的免疫识别中的作用。

Front Cell Dev Biol. 2016 Sep 12;4:97. doi: 10.3389/fcell.2016.00097. eCollection 2016.

A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008.GPI 锚解释了共同的 NKG2D 配体等位基因 MICA*008 的独特生物学特征。

Biochem J. 2013 Sep 1;454(2):295-302. doi: 10.1042/BJ20130194.

Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1-3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP-recipient natural killer cells.人类NKG2D配体UL16结合蛋白（ULBP）1 - 3的转移与溶细胞颗粒释放相关，并导致配体重新转移以及对ULBP受体自然杀伤细胞的杀伤。

Immunology. 2015 Sep;146(1):70-80. doi: 10.1111/imm.12482. Epub 2015 Jun 25.

Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma.作为人类神经母细胞瘤免疫逃逸策略的NKG2D配体下调和/或释放

Neoplasia. 2004 Sep-Oct;6(5):558-68. doi: 10.1593/neo.04316.

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity.不同组织类型肿瘤细胞系上主要组织相容性复合体I类相关链A和UL16结合蛋白的表达：肿瘤对NKG2D依赖性自然杀伤细胞细胞毒性的易感性分析

Cancer Res. 2002 Nov 1;62(21):6178-86.

Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression.可溶性ULBP通过下调NKG2D表达来抑制自然杀伤细胞活性。

Cell Immunol. 2006 Jan;239(1):22-30. doi: 10.1016/j.cellimm.2006.03.002. Epub 2006 Apr 21.

Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance.癌症外泌体与 NKG2D 受体配体相互作用：抑制 NKG2D 介导的细胞毒性和抗肿瘤免疫监视。

Semin Cancer Biol. 2014 Oct;28:24-30. doi: 10.1016/j.semcancer.2014.02.010. Epub 2014 Mar 3.

Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.应激诱导蛋白ULBP和MICA的细胞表面组织，其通过NKG2D刺激人自然杀伤细胞和T细胞。

J Exp Med. 2004 Apr 5;199(7):1005-10. doi: 10.1084/jem.20032194. Epub 2004 Mar 29.

Soluble ligands for the NKG2D receptor are released during HIV-1 infection and impair NKG2D expression and cytotoxicity of NK cells.可溶性 NKG2D 受体配体在 HIV-1 感染过程中释放，并损害 NK 细胞的 NKG2D 表达和细胞毒性。

FASEB J. 2013 Jun;27(6):2440-50. doi: 10.1096/fj.12-223057. Epub 2013 Feb 8.

引用本文的文献

Immunoassays for scarce tumour-antigens in exosomes: detection of the human NKG2D-Ligand, MICA, in tetraspanin-containing nanovesicles from melanoma.外泌体中稀有肿瘤抗原的免疫分析：在含有四跨膜蛋白的纳米囊泡中检测黑色素瘤的人类 NKG2D-Ligand（MICA）。

J Nanobiotechnology. 2018 May 2;16(1):47. doi: 10.1186/s12951-018-0372-z.

Disarming Cellular Alarm Systems-Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses.解除细胞警报系统——人类疱疹病毒对应激诱导的NKG2D配体的操控

Front Immunol. 2017 Apr 11;8:390. doi: 10.3389/fimmu.2017.00390. eCollection 2017.

Front Cell Dev Biol. 2016 Sep 12;4:97. doi: 10.3389/fcell.2016.00097. eCollection 2016.

MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.MICA*A4可预防溃疡性结肠炎，而MICA*A5.1与脓肿形成及发病年龄有关。

Clin Exp Immunol. 2016 Jun;184(3):323-31. doi: 10.1111/cei.12786. Epub 2016 Apr 5.

本文引用的文献

Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA∗008 to Escape Elimination by NK Cells.宿主与病原体的动态协同进化：人巨细胞病毒下调常见等位基因MICA∗008以逃避自然杀伤细胞的清除

Cell Rep. 2015 Feb 17;10(6):968-982. doi: 10.1016/j.celrep.2015.01.029. Epub 2015 Feb 12.

The role of microRNAs in the control of innate immune response in cancer.微小 RNA 在癌症中固有免疫反应调控中的作用。

J Natl Cancer Inst. 2014 Sep 12;106(10). doi: 10.1093/jnci/dju257. Print 2014 Oct.

N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.天冬酰胺8的N-糖基化调节主要组织相容性复合体I类链相关蛋白A（MICA）等位基因的表面表达，该表达依赖于苏氨酸24。

J Biol Chem. 2014 Jul 18;289(29):20078-91. doi: 10.1074/jbc.M114.573238. Epub 2014 May 28.

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation.两种新型人类巨细胞病毒自然杀伤细胞逃避功能靶向MICA进行溶酶体降解。

PLoS Pathog. 2014 May 1;10(5):e1004058. doi: 10.1371/journal.ppat.1004058. eCollection 2014 May.

Biosynthesis and deficiencies of glycosylphosphatidylinositol.糖基磷脂酰肌醇的生物合成与缺陷。

Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(4):130-43. doi: 10.2183/pjab.90.130.

Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer.天然配体和抗体融合蛋白：利用免疫系统对抗癌症。

Trends Mol Med. 2014 Feb;20(2):72-82. doi: 10.1016/j.molmed.2013.10.006. Epub 2013 Nov 19.

A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008.GPI 锚解释了共同的 NKG2D 配体等位基因 MICA*008 的独特生物学特征。

Biochem J. 2013 Sep 1;454(2):295-302. doi: 10.1042/BJ20130194.

Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications.可溶性 NKG2D 配体的产生：蛋白水解切割、外泌体分泌及其功能意义。

Scand J Immunol. 2013 Aug;78(2):120-9. doi: 10.1111/sji.12072.

MICA variant promotes allosensitization after kidney transplantation.MICA 变体可促进肾移植后的同种异体致敏。

J Am Soc Nephrol. 2013 May;24(6):954-66. doi: 10.1681/ASN.2012080814. Epub 2013 Mar 28.

Transport of glycosylphosphatidylinositol-anchored proteins from the endoplasmic reticulum.糖基磷脂酰肌醇锚定蛋白从内质网的转运

Biochim Biophys Acta. 2013 Nov;1833(11):2473-8. doi: 10.1016/j.bbamcr.2013.01.027. Epub 2013 Feb 1.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验