El-Megharbel Samy M, El-Metwaly Nashwa M, Refat Moamen S
Department of Chemistry, Faculty of Science, Taif University, Taif 888, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Egypt.
Department of Chemistry, Faculty of Science, Mansoura University, Egypt; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
Spectrochim Acta A Mol Biomol Spectrosc. 2015;149:263-70. doi: 10.1016/j.saa.2015.04.069. Epub 2015 Apr 30.
Three urate chelations were obtained when uric acid was reacted with UO2(CH3COO)2H2O, VOSO4·XH2O and ZrOCl2·XH2O salts with neutralized with 0.1 M NaOH aqueous media. The 1:2 metal-to-ligand complexes (UO2)2(C5H2N4O3)2, [(ZrO)2(H2O)2(C5H2N4O3)2] and [VO((C5H3N4O3)2] were characterized by elemental analyses, molar conductivity, (infrared, Raman and UV-vis) spectra, effective magnetic moment in Bohr magnetons, and thermal analysis (TG/DTG). The urate ligand coordinates as mononegative bidentate donor towards the mononuclear central vanadium atom and coordinated as binegative tetradentate mode towards the binuclear dioxouranium and zirconyl centers. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with uric acid. The ligand, ZrO(II) and UO2(II) complex showed a week potential degradation on calf thymus DNA, whereas VO(II) complex slightly degraded the DNA.
当尿酸与用0.1 M NaOH水溶液中和的UO2(CH3COO)2H2O、VOSO4·XH2O和ZrOCl2·XH2O盐反应时，得到了三种尿酸螯合物。通过元素分析、摩尔电导率、（红外、拉曼和紫外可见）光谱、以玻尔磁子为单位的有效磁矩以及热分析（TG/DTG）对1:2的金属-配体配合物(UO2)2(C5H2N4O3)2、[(ZrO)2(H2O)2(C5H2N4O3)2]和[VO((C5H3N4O3)2]进行了表征。尿酸配体作为单负二齿供体与单核中心钒原子配位，并作为双负四齿模式与双核二氧化铀和锆酰中心配位。测试了金属配合物对某些细菌和真菌菌株的抗菌活性，并与尿酸进行了比较。配体、ZrO(II)和UO2(II)配合物对小牛胸腺DNA显示出微弱的潜在降解作用，而VO(II)配合物对DNA有轻微降解。
