Sarna S K, Lang I M
Department of Surgery, Medical College of Wisconsin, Milwaukee.
Am J Physiol. 1989 Nov;257(5 Pt 1):G830-5. doi: 10.1152/ajpgi.1989.257.5.G830.
We investigated the effects of ingestion of a meal on colonic motor activity in six conscious dogs, each instrumented with seven strain-gauge transducers to record circular muscle contractions. A 1,300-kcal meal was given after a 4-h control recording. The post-prandial period of 8 h was subdivided into an early period lasting 2 h and a late period lasting 6 h. The ingestion of the meal did not disrupt the colonic migrating myoelectric complexes (CMMCs) but prolonged their cycle length in the early postprandial period. The cycle length was not different from the control during the late postprandial period. The mean and total duration of contractile activity per hour increased significantly during the early postprandial period in the distal colon but not in the proximal or the middle colon. During the late postprandial period the mean and total duration of contractile activity per hour increased significantly throughout the colon. Giant migrating contractions occurred rarely during the 8-h postprandial period. We conclude that different parts of the colon respond to the ingestion of a meal in different ways. The response also depends on whether the fresh digesta has reached the colon. The late postprandial response is likely to be due to the entry of fresh digesta into the colon.
我们研究了进食对6只清醒犬结肠运动活性的影响，每只犬均安装了7个应变片式传感器以记录环形肌收缩。在4小时的对照记录后给予1300千卡的餐食。餐后8小时分为持续2小时的早期和持续6小时的晚期。进食并未破坏结肠移行性肌电复合波（CMMCs），但在餐后早期延长了其周期长度。餐后晚期的周期长度与对照无差异。餐后早期，远端结肠每小时收缩活动的平均时长和总时长显著增加，而近端和中段结肠则无此变化。餐后晚期，整个结肠每小时收缩活动的平均时长和总时长均显著增加。餐后8小时内很少出现巨大移行性收缩。我们得出结论，结肠的不同部位对进食的反应方式不同。这种反应还取决于新鲜食糜是否到达结肠。餐后晚期的反应可能是由于新鲜食糜进入结肠所致。
