Cao L-H, Liu Z-M, Zhao P-L, Sun S-C, Xu D-B, Shao M-H, Zhang J-D
Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China
Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
Genet Mol Res. 2015 May 4;14(2):4651-7. doi: 10.4238/2015.May.4.24.
The aim of this study was to examine the efficacy of combined immunization of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (HBVac) in blocking father-infant transmission of hepatitis B virus (HBV). Newborns positive at birth for blood HBV sur-face antigen (HBsAg) and/or HBV DNA were selected and immunized with HBIG combination HBVac. At 7 months, HBV markers and HBV DNA of each neonate were measured using electrochemiluminescence with the Cobas-e-411 Automatic Electrochemiluminescence Immuno-assay Analyzer and fluorescence quantitative polymerase chain reaction. Among all 7-month-old subjects, the negative conversion rates of HBV DNA and HBsAg were 48/61 (78.7%) and 19/41 (46.3%), respectively. Therefore, this study demonstrated that prompt combination injection of HBIG and HBVac can protect some of the HBV DNA- and/ or HBsAg-positive newborns from HBV.
本研究旨在探讨乙型肝炎免疫球蛋白（HBIG）与乙型肝炎疫苗（HBVac）联合免疫在阻断乙肝病毒（HBV）父婴传播中的效果。选取出生时血液乙肝表面抗原（HBsAg）和/或HBV DNA呈阳性的新生儿，采用HBIG联合HBVac进行免疫。7个月时，使用Cobas-e-411全自动电化学发光免疫分析分析仪通过电化学发光法以及荧光定量聚合酶链反应检测每个新生儿的HBV标志物和HBV DNA。在所有7个月大的受试者中，HBV DNA和HBsAg的阴转率分别为48/61（78.7%）和19/41（46.3%）。因此，本研究表明，及时联合注射HBIG和HBVac可使部分HBV DNA和/或HBsAg阳性新生儿免受HBV感染。
