Rowold Diane J, Perez Benedico David, Garcia-Bertrand Ralph, Chennakrishnaiah Shilpa, Alfonso-Sanchez Miguel A, Gayden Tenzin, Herrera Rene J
Foundation for Applied Molecular Evolution, Gainesville, Florida, USA.
Department of Biology, Miami Dade College, Miami, Florida, USA.
Eur J Hum Genet. 2016 Mar;24(3):442-9. doi: 10.1038/ejhg.2015.80. Epub 2015 May 13.
Owing to its geographic location near the longitudinal center of Asia, Ladakh, the land of high passes, has witnessed numerous demographic movements during the past millenniums of occupation. In an effort to view Ladakh's multicultural history from a paternal genetic perspective, we performed a high-resolution Y-chromosomal survey of Ladakh, within the context of Y haplogroup and haplotype distributions of 41 Asian reference populations. The results of this investigation highlight the rich ethnic and genetic diversity of Ladkah which includes genetic contributions from disparate regions of the continent including, West, East, South and Central Asia. The phylogenetic signals from Ladakh are consistent with the Indo-Aryans' occupation during the Neolithic age and its historic connection with Tibet, as well as the East-West gene flow associated with the Silk Road.
拉达克，这片拥有众多山口的土地，因其地理位置靠近亚洲的纵向中心，在过去数千年的人类居住历史中见证了无数次人口迁移。为了从父系基因的角度审视拉达克的多元文化历史，我们在41个亚洲参考人群的Y单倍群和单倍型分布的背景下，对拉达克进行了高分辨率的Y染色体调查。这项调查结果凸显了拉达克丰富的种族和基因多样性，其中包括来自亚洲大陆不同地区（包括西亚、东亚、南亚和中亚）的基因贡献。拉达克的系统发育信号与新石器时代印度-雅利安人的占领、其与西藏的历史联系以及与丝绸之路相关的东西方基因流动相一致。
